TSC22D4 and MAD2L1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		TSC22D4	MAD2L1
Gene Name		TSC22 domain family, member 4	MAD2 mitotic arrest deficient-like 1 (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nuclear Pore Cytosol Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of APC-Cdc20 Complex Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways			Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			F-cell distribution ( 21326311) HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580	20 interactors: ADAM17 ANAPC2 APP CDC16 CDC20 CDC27 CSF2RB ESR2 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TSC22D4 UBD
Entrez ID		81628	4085
HPRD ID		18231	03274
Ensembl ID		ENSG00000166925
Uniprot IDs		A8MWR6 Q9Y3Q8	Q13257
PDB IDs			1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Mitotic Cell Cycle Checkpoint Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Regulation Of Cellular Component Organization Mitotic Nuclear Division Negative Regulation Of Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Processing Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Protein Processing Negative Regulation Of Protein Ubiquitination Regulation Of Proteolysis Cell Division Negative Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting	aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle
Tagcloud (Difference) ?		ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting	aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle
Tagcloud (Intersection) ?