TSC22D4 and MAD2L1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		TSC22D4	MAD2L1
Description		TSC22 domain family member 4	mitotic arrest deficient 2 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Dendrite Cell Projection Synapse	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Mitotic Checkpoint Complex Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Glucose Homeostasis Negative Regulation Of DNA-templated Transcription Neuron Cellular Homeostasis Neuron Projection Extension	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Regulation Of Nuclear Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways			Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Coronary artery disease ( 28714974 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Myocardial infarction ( 33532862) Refractive error ( 32231278)
Interacting Genes		61 interacting genes: ABLIM1 AIFM1 ARHGAP9 BLZF1 CBX8 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU CTNNAL1 ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO1 LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP MYO15B NIF3L1 NOC4L NRBP1 PCBP1 PCDH17 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TRIM55 TRIM63 TSC22D1 TSPOAP1 UBLCP1 VBP1 ZBTB24 ZMYND10 ZNF580	25 interacting genes: ADAM17 ANAPC2 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		81628	4085
HPRD ID		18231	03274
Ensembl ID		ENSG00000166925	ENSG00000164109
Uniprot IDs		B4DKI8 Q9Y3Q8	Q13257
PDB IDs			1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Binding Organelle Organization Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Cytoplasm Negative Regulation Of Protein Metabolic Process Regulation Of Protein Stability Negative Regulation Of Amyloid-beta Formation Cellular Response To Glucose Stimulus Phosphothreonine Residue Binding Cellular Response To Hydrogen Peroxide Protein Localization To Lipid Droplet Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Carbohydrate Stimulus Organelle Disassembly Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Regulation Of Amide Metabolic Process Protein Stabilization Regulation Of Protein Metabolic Process Viral RNA Genome Replication Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Intracellular Glucose Homeostasis Protein Ubiquitination Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Ubiquitin-protein Transferase Activator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Separation Regulation Of Nuclear Division Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex Regulation Of Cell Cycle Process Regulation Of Meiotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Metaphase/anaphase Transition Of Cell Cycle Cell Division Regulation Of Reproductive Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Phase Transition Spindle Negative Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint PTB Domain Binding Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cell Cycle Meiotic Cell Cycle Phase Transition Zeta DNA Polymerase Complex Negative Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Growth
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