TSC22D4 and MYLIP

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TSC22D4	MYLIP
Gene Name		TSC22 domain family, member 4	myosin regulatory light chain interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Intracellular Cytoplasm Cytoskeleton Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated	Movement Of Cell Or Subcellular Component Nervous System Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580	15 interactors: CNPY2 KDM1A LDLR LRP8 MIPOL1 MTAP MYL12B RASSF5 TSC22D4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR
Entrez ID		81628	29116
HPRD ID		18231	17621
Ensembl ID		ENSG00000166925	ENSG00000007944
Uniprot IDs		A8MWR6 Q9Y3Q8	Q5TIA5 Q8WY64
PDB IDs			2YHN 2YHO
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Protein K48-linked Ubiquitination Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Reelin-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Negative Regulation Of Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Response To Stimulus Positive Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting	aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations
Tagcloud (Difference) ?		ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting	aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations
Tagcloud (Intersection) ?