ANP32E and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		ANP32E	UCHL5
Description		acidic nuclear phosphoprotein 32 family member E	ubiquitin C-terminal hydrolase L5
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GO Annotations	Cellular Component	Swr1 Complex Nucleus Cytoplasm Synaptic Vesicle Membrane Cytoplasmic Vesicle Postsynaptic Density Membrane Postsynaptic Endosome Membrane Glutamatergic Synapse	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Protein Binding Phosphatase Inhibitor Activity Histone Binding Protein Folding Chaperone Histone Chaperone Activity	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Chromatin Organization Protein Folding Regulation Of Apoptotic Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways			Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Neutrophil percentage of white cells ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Cannabis dependence ( 21668797)
Interacting Genes		6 interacting genes: FBXO7 FOS PTEN SMAD2 UBC UCHL5	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		81611	51377
HPRD ID		16493	10293
Ensembl ID		ENSG00000143401	ENSG00000116750
Uniprot IDs		B4E0D5 E9PLC4 Q9BTT0	Q5LJA5 Q9Y5K5
PDB IDs		4CAY 4NFT	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Forebrain Morphogenesis SMAD Protein Signal Transduction R-SMAD Binding Macromolecule Metabolic Process Medium-term Memory Cellular Response To Prolactin Response To Transforming Growth Factor Beta Ubiquitin Protein Ligase Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Mitochondrial Threonyl-tRNA Aminoacylation Response To Prolactin Double-stranded DNA Binding Conditioned Taste Aversion Nucleoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Homomeric SMAD Protein Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Modification-dependent Protein Catabolic Process Lewy Body Core Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Cytoplasm Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Mesoderm Morphogenesis Pericardium Development Protein Modification Process	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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