CPTP and INPP5K

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CPTP	INPP5K
Description		ceramide-1-phosphate transfer protein	inositol polyphosphate-5-phosphatase K
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane	Ruffle Nucleus Cytoplasm Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Membrane Ruffle Membrane Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Phospholipid Binding Lipid Binding Lipid Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Vasopressin Receptor Activity Protein Binding Inositol Bisphosphate Phosphatase Activity Hydrolase Activity Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Trisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Lipid Transport Negative Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Ceramide Transport Glycolipid Transport Intermembrane Lipid Transfer Negative Regulation Of NLRP3 Inflammasome Complex Assembly Ceramide 1-phosphate Transport	In Utero Embryonic Development Regulation Of Glycogen Biosynthetic Process Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of D-glucose Transmembrane Transport Actin Cytoskeleton Organization Response To Insulin Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Negative Regulation Of Dephosphorylation Positive Regulation Of Urine Volume Glucose Homeostasis Host-mediated Suppression Of Viral Transcription Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Glycerolipid Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Dephosphorylation Regulation Of Transport Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Calcium Ion Transport Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Protein Targeting To Membrane Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Renal Water Transport
Pathways		Glycosphingolipid transport	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS			Mean platelet volume ( 27863252)
Interacting Genes		7 interacting genes: CD7 ECM1 ELOC INPP5K PHF13 SMAD3 ZNF451	23 interacting genes: ANXA7 ARL6IP1 ATP5PF BDNF CDKN1A CPTP FADS6 FATE1 FBXO7 GOLT1B HMOX2 HSPB1 KRT31 NCOR2 PBX3 PFDN1 SFT2D2 SMN1 TANK TK1 TNFRSF10D TNKS TTR
Entrez ID		80772	51763
HPRD ID		18878	08489
Ensembl ID		ENSG00000224051	ENSG00000132376
Uniprot IDs		Q5TA50 S4S694	B7Z4V9 Q9BT40
PDB IDs		4K80 4K84 4K85 4K8N 4KBS 4KF6
Enriched GO Terms of Interacting Partners?		Regulation Of Bone Mineralization Negative Regulation Of Ossification Transcription Corepressor Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Renal Water Transport Phosphatidylinositol Trisphosphate Phosphatase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Ossification Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Interleukin-2 Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Sterol Response Element Binding Carbohydrate Homeostasis Transdifferentiation Glucose Homeostasis Positive Regulation Of Transforming Growth Factor Beta3 Production SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Regulation Of Lung Blood Pressure Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Heteromeric SMAD Protein Complex Regulation Of Stress Fiber Assembly Trophoblast Cell Migration Immune System Development Regulation Of Transforming Growth Factor Beta2 Production Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Bisphosphate Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Negative Regulation Of Dephosphorylation Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Vasopressin Receptor Activity Negative Regulation Of Protein Targeting To Membrane Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response
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