CPTP and ECM1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CPTP	ECM1
Description		ceramide-1-phosphate transfer protein	extracellular matrix protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane	Extracellular Region Extracellular Space Extracellular Matrix Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Phospholipid Binding Lipid Binding Lipid Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity	Protease Binding Interleukin-2 Receptor Binding Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Lipid Transport Negative Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Ceramide Transport Glycolipid Transport Intermembrane Lipid Transfer Negative Regulation Of NLRP3 Inflammasome Complex Assembly Ceramide 1-phosphate Transport	Ossification Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Development Regulation Of Type 2 Immune Response Endochondral Bone Growth Regulation Of Transcription By RNA Polymerase II Inflammatory Response Signal Transduction Negative Regulation Of Peptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of T Cell Migration
Pathways		Glycosphingolipid transport	Platelet degranulation
Drugs
Diseases			Lipoid proteinosis; Urbach-Wiethe disease
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spontaneous coronary artery dissection ( 32374345 32887874) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: CD7 ECM1 ELOC INPP5K PHF13 SMAD3 ZNF451	39 interacting genes: A1CF ACTN3 AIRIM ATN1 BCAS2 BNIP3L CPTP CYSRT1 DDIAS DTX2 ENKD1 FASLG FBLN1 FKBP6 FRS3 FXR1 GCM2 GNE GPANK1 GRN HOXC8 HSPG2 IRAK3 ITGB4 KLHL38 KRTAP5-3 KRTAP9-3 LCE2A LIN7A LMO4 MKRN3 PRKAR2B RERE SAMD11 SGTB SNRPC SRPK1 UBQLN1 UBQLN2
Entrez ID		80772	1893
HPRD ID		18878	03727
Ensembl ID		ENSG00000224051	ENSG00000143369
Uniprot IDs		Q5TA50 S4S694	A0A140VJI7 Q16610
PDB IDs		4K80 4K84 4K85 4K8N 4KBS 4KF6
Enriched GO Terms of Interacting Partners?		Regulation Of Bone Mineralization Negative Regulation Of Ossification Transcription Corepressor Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Renal Water Transport Phosphatidylinositol Trisphosphate Phosphatase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Ossification Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Interleukin-2 Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Sterol Response Element Binding Carbohydrate Homeostasis Transdifferentiation Glucose Homeostasis Positive Regulation Of Transforming Growth Factor Beta3 Production SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Regulation Of Lung Blood Pressure Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Heteromeric SMAD Protein Complex Regulation Of Stress Fiber Assembly Trophoblast Cell Migration Immune System Development Regulation Of Transforming Growth Factor Beta2 Production Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Bisphosphate Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Negative Regulation Of Dephosphorylation Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Vasopressin Receptor Activity Negative Regulation Of Protein Targeting To Membrane Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response	Embryo Implantation
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