SRCIN1 and BCAR1

Number of citations of the paper that reports this interaction (PMID 14657239)
10

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SRCIN1	BCAR1
Gene Name		SRC kinase signaling inhibitor 1	breast cancer anti-estrogen resistance 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Focal Adhesion Postsynaptic Density Actin Cytoskeleton Axon Dendrite Synapse Postsynaptic Membrane	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Protein Binding Protein Kinase Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Exocytosis Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways			Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		4 interactors: BCAR1 SNAP25 SORBS3 SRC	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		80725	9564
HPRD ID		11589	04248
Ensembl ID		ENSG00000017373	ENSG00000050820
Uniprot IDs		Q9C0H9	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs			1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Progesterone Stimulus Organelle Organization Platelet Activation Cytoskeleton Organization Cell-substrate Adhesion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cell Adhesion Neurotrophin Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Insulin Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cellular Component Biogenesis Regulation Of Podosome Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Caveolin-mediated Endocytosis Cellular Protein Complex Assembly Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Synaptic Vesicle Docking Cellular Response To Hepatocyte Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Osteoclast Development Synaptic Vesicle Priming Negative Regulation Of Protein Oligomerization Regulation Of Protein Secretion Positive Regulation Of Organelle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Integrin Activation Blood Coagulation Hemostasis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?			aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?			aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?