SRCIN1 and SNAP25

Number of citations of the paper that reports this interaction (PMID 10625663)
22

Data Source:
HPRD (two hybrid, in vitro)

		SRCIN1	SNAP25
Gene Name		SRC kinase signaling inhibitor 1	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Focal Adhesion Postsynaptic Density Actin Cytoskeleton Axon Dendrite Synapse Postsynaptic Membrane	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	Protein Binding Protein Kinase Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways			Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		4 interactors: BCAR1 SNAP25 SORBS3 SRC	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		80725	6616
HPRD ID		11589	02637
Ensembl ID		ENSG00000017373	ENSG00000132639
Uniprot IDs		Q9C0H9	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Progesterone Stimulus Organelle Organization Platelet Activation Cytoskeleton Organization Cell-substrate Adhesion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cell Adhesion Neurotrophin Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Insulin Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cellular Component Biogenesis Regulation Of Podosome Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Caveolin-mediated Endocytosis Cellular Protein Complex Assembly Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Synaptic Vesicle Docking Cellular Response To Hepatocyte Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Osteoclast Development Synaptic Vesicle Priming Negative Regulation Of Protein Oligomerization Regulation Of Protein Secretion Positive Regulation Of Organelle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Integrin Activation Blood Coagulation Hemostasis	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?			anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?			anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?