SRCIN1 and SNAP25

Number of citations of the paper that reports this interaction (PubMedID 10625663)
0

Data Source:
HPRD (two hybrid, in vitro)

		SRCIN1	SNAP25
Description		SRC kinase signaling inhibitor 1	synaptosome associated protein 25
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Postsynaptic Density Actin Cytoskeleton Axon Dendrite Cell Projection Synapse Presynapse Postsynapse Glutamatergic Synapse	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase Binding	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Postsynaptic Actin Cytoskeleton Organization	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs			Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Rate of ventricular enlargement ( 31711042)	Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		6 interacting genes: ABL1 BCAR1 FBXO7 SNAP25 SORBS3 SRC	45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		80725	6616
HPRD ID		11589	02637
Ensembl ID		ENSG00000277363	ENSG00000132639
Uniprot IDs		Q9C0H9	P60880
PDB IDs			1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
Enriched GO Terms of Interacting Partners?		ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell-substrate Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cell Projection Organization Ephrin Receptor Binding Actin Filament Organization Cellular Response To Fluid Shear Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cell Adhesion Response To Fluid Shear Stress SH2 Domain Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Substrate Adhesion-dependent Cell Spreading Autophagy Response To Growth Factor Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Locomotion Regulation Of Focal Adhesion Assembly Cellular Response To Hydrogen Peroxide Regulation Of Mitochondrial Membrane Potential Response To Transforming Growth Factor Beta Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Focal Adhesion Regulation Of Cell-substrate Junction Organization Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Binding Protein Localization To Cytoplasmic Microtubule Plus-end Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite	SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport
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