SRCIN1 and SORBS3

Number of citations of the paper that reports this interaction (PMID 18662323)
4

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SRCIN1	SORBS3
Gene Name		SRC kinase signaling inhibitor 1	sorbin and SH3 domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Focal Adhesion Postsynaptic Density Actin Cytoskeleton Axon Dendrite Synapse Postsynaptic Membrane	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protein Binding Protein Kinase Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Exocytosis Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS			HIV-1 control ( 20205591)
Protein-Protein Interactions		4 interactors: BCAR1 SNAP25 SORBS3 SRC	46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		80725	10174
HPRD ID		11589	11535
Ensembl ID		ENSG00000017373	ENSG00000120896
Uniprot IDs		Q9C0H9	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Progesterone Stimulus Organelle Organization Platelet Activation Cytoskeleton Organization Cell-substrate Adhesion Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cell Adhesion Neurotrophin Signaling Pathway Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Insulin Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cellular Component Biogenesis Regulation Of Podosome Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Caveolin-mediated Endocytosis Cellular Protein Complex Assembly Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Synaptic Vesicle Docking Cellular Response To Hepatocyte Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Osteoclast Development Synaptic Vesicle Priming Negative Regulation Of Protein Oligomerization Regulation Of Protein Secretion Positive Regulation Of Organelle Organization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Integrin Activation Blood Coagulation Hemostasis	Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process
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