CAPN7 and MDM4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CAPN7	MDM4
Gene Name		calpain 7	MDM4, p53 regulator
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding MIT Domain Binding	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Positive Regulation Of Epithelial Cell Migration Self Proteolysis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process G0 To G1 Transition Protein Stabilization Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535733) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Prostate cancer ( 23535732)
Protein-Protein Interactions		7 interactors: IST1 MDM4 TNFAIP1 UBL7 VHL ZBTB9 ZFYVE19	42 interactors: AKT1 APP ARF1 ATM CAPN7 CASP3 CD160 CDK1 CHEK1 CHEK2 CSNK1A1 E2F1 EP300 LRSAM1 MDM2 MKRN3 MNAT1 PRKAA1 RAD54B RB1 RN5S1@ RNF115 SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		23473	4194
HPRD ID		05908	04082
Ensembl ID		ENSG00000131375	ENSG00000198625
Uniprot IDs		Q7Z479 Q9Y6W3	O15151 Q59FS6 Q68DC0
PDB IDs		2QFE	2CR8 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3U15
Enriched GO Terms of Interacting Partners?		Abscission Protein Stabilization Viral Capsid Secondary Envelopment Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels G0 To G1 Transition Regulation Of Protein Stability Viral Release From Host Cell Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Collateral Sprouting Response To Hypoxia Negative Regulation Of Cytokinesis Stress Fiber Assembly Cell Division Negative Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Regulation Of Cell Cycle Process Negative Regulation Of Rho Protein Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Response To Abiotic Stimulus Cellular Response To Stress Cell Cycle Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Hypoxia Positive Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Response To Oxygen Levels Response To Stress Regulation Of Cell Death Cellular Response To Stimulus Regulation Of Intracellular Transport Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Signal Transduction Regulation Of Cellular Component Organization Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction
Tagcloud ?			aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Difference) ?			aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Intersection) ?