CAPN7 and PRPSAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CAPN7	PRPSAP1
Description		calpain 7	phosphoribosyl pyrophosphate synthetase associated protein 1
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Extracellular Exosome	Cytoplasm
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity MIT Domain Binding	Magnesium Ion Binding Enzyme Inhibitor Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	Proteolysis Positive Regulation Of Epithelial Cell Migration Self Proteolysis	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) High-grade serous ovarian cancer ( 31469419) Nontraumatic osteonecrosis of the femoral head ( 32701715) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Urate levels ( 23263486)
Interacting Genes		19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655	8 interacting genes: CAPN7 DDX19B MAGOHB MAPK1 PLEKHF2 PRPS1 PRPS2 UBE2I
Entrez ID		23473	5635
HPRD ID		05908	03151
Ensembl ID		ENSG00000131375	ENSG00000161542
Uniprot IDs		Q7Z479 Q9Y6W3	B4DP31 Q14558
PDB IDs		2QFE 8UC6	2C4K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Population Proliferation Identical Protein Binding Cell Division Negative Regulation Of Catabolic Process Regulation Of Cell Cycle Centrosome Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cytoplasm Ubiquitin-protein Transferase Activity Negative Regulation Of Autophagy Atrioventricular Valve Morphogenesis Negative Regulation Of Cell Cycle Process Midbody Abscission Regulation Of Primary Metabolic Process Mitotic Cytokinetic Process Mitotic Spindle Protein Ubiquitination Flemming Body Spindle Pole Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytokinetic Process Regulation Of Cell Cycle Process Molecular Adaptor Activity MAD1 Complex Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Heart Valve Morphogenesis Proteasomal Protein Catabolic Process Post-translational Protein Modification Transcription Repressor Complex Protein Stabilization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Ribose Phosphate Diphosphokinase Activity 5-phosphoribose 1-diphosphate Biosynthetic Process Nuclear Export ATP Binding Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nuclear Transport Nucleocytoplasmic Transport Pyrimidine-containing Compound Metabolic Process Nucleotide Binding Ribose Phosphate Diphosphokinase Complex Nucleoside Monophosphate Metabolic Process SUMO Conjugating Enzyme Activity MRNA Export From Nucleus RNA Export From Nucleus Nuclear Pore Cytosine Metabolic Process Urate Biosynthetic Process Interleukin-34-mediated Signaling Pathway Hypoxanthine Biosynthetic Process RING-like Zinc Finger Domain Binding Intracellular Transport MIT Domain Binding Exon-exon Junction Subcomplex Mago-y14 Nucleobase-containing Small Molecule Metabolic Process Caveolin-mediated Endocytosis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Positive Regulation Of Locomotion Kinase Activity Hypoxanthine Metabolic Process Ribose Phosphate Biosynthetic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding RNA Transport MRNA Transport Purine Nucleotide Biosynthetic Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Localization Establishment Of Localization In Cell Outer Ear Morphogenesis ERBB3 Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation
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