TXNDC17 and TXNRD1

Number of citations of the paper that reports this interaction (PubMedID 14607844)
0

Data Source:
HPRD (in vitro)

		TXNDC17	TXNRD1
Description		thioredoxin domain containing 17	thioredoxin reductase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Peroxidase Activity Protein Binding Protein-disulfide Reductase [NAD(P)H] Activity	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Identical Protein Binding NADPH Peroxidase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Oxidant Detoxification	Mesoderm Formation Signal Transduction Gastrulation Cell Population Proliferation Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways			PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)
Interacting Genes		9 interacting genes: AVP DYNLL1 EXOSC8 INCA1 INS OXT RUFY1 TINF2 TXNRD1	12 interacting genes: CEBPA DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP
Entrez ID		84817	7296
HPRD ID		11656	03068
Ensembl ID		ENSG00000129235	ENSG00000198431
Uniprot IDs		A0A140VJY7 Q9BRA2	B7Z2S5 Q16881
PDB IDs		1WOU	2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB 7X1R
Enriched GO Terms of Interacting Partners?		Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Grooming Behavior Positive Regulation Of Secretion Hormone Activity Positive Regulation Of Secretion By Cell Maternal Behavior Parental Behavior Secretory Granule Mating Behavior Neuronal Dense Core Vesicle Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Reproductive Behavior Identical Protein Binding Response To Electrical Stimulus Regulation Of Secretion By Cell Regulation Of Secretion Social Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding NADPH Peroxidase Activity Positive Regulation Of Transport Regulation Of Amine Transport V1A Vasopressin Receptor Binding Regulation Of Transport Negative Regulation Of Glycogen Catabolic Process Regulation Of Hindgut Contraction Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Perinucleolar Chromocenter Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Penile Erection Positive Regulation Of Norepinephrine Secretion Positive Regulation Of Female Receptivity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Cell Growth Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance	Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Response To Estradiol Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway TBP-class Protein Binding Steroid Binding Negative Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estradiol Stimulus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Transcription Cis-regulatory Region Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Arsenate Reductase (glutaredoxin) Activity Enzyme Inhibitor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Glutathione Disulfide Oxidoreductase Activity Regulation Of DNA-templated Transcription Initiation
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