TXNDC17 and TXNRD1

Number of citations of the paper that reports this interaction (PMID 14607844)
12

Data Source:
HPRD (in vitro)

		TXNDC17	TXNRD1
Gene Name		thioredoxin domain containing 17	thioredoxin reductase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Peroxidase Activity Protein Binding Electron Carrier Activity Protein-disulfide Reductase Activity	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Oxidation-reduction Process	Response To Reactive Oxygen Species Signal Transduction Nucleobase-containing Small Molecule Interconversion Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Uptake and actions of bacterial toxins Metabolism of lipids and lipoproteins Detoxification of Reactive Oxygen Species Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Uptake and function of diphtheria toxin
Drugs			Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin-Adenine Dinucleotide Spermidine Fotemustine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AVP DYNLL1 EXOSC8 INS OXT RUFY1 TINF2 TXNRD1	8 interactors: DMRTC2 FOXO1 GLRX2 POU2F1 POU2F2 PPP1R16A TXNDC17 TXNIP
Entrez ID		84817	7296
HPRD ID		11656	03068
Ensembl ID		ENSG00000129235	ENSG00000198431
Uniprot IDs		Q9BRA2	B7Z1F4 B7Z2S5 B7Z904 E7EW10 Q16881
PDB IDs		1WOU	1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?		Maternal Aggressive Behavior Hyperosmotic Salinity Response Aggressive Behavior Regulation Of Cellular Component Organization Regulation Of Female Receptivity Maternal Behavior Female Mating Behavior Grooming Behavior Regulation Of Renal Sodium Excretion Copulation Hyperosmotic Response Regulation Of Excretion Homeostatic Process Mating Behavior Positive Regulation Of Transport Response To Salt Stress Positive Regulation Of Blood Pressure Social Behavior Positive Regulation Of Secretion Mating Regulation Of Organelle Organization Regulation Of Neurological System Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Hindgut Contraction Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Regulation Of Mitochondrion Organization Renal System Process Regulation Of Protein ADP-ribosylation Negative Regulation Of Glycogen Catabolic Process Regulation Of Hindgut Contraction Ion Homeostasis Positive Regulation Of Cell Growth Regulation Of DNA Replication Regulation Of Lipid Biosynthetic Process Regulation Of Anion Transport Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Secretion Positive Regulation Of DNA Metabolic Process Response To Alkaloid Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Regulation Of Ion Homeostasis Positive Regulation Of Cellular PH Reduction Positive Regulation Of Norepinephrine Secretion	Response To Reactive Oxygen Species Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Response To Oxidative Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Cellular Response To Tumor Cell Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immunoglobulin Secretion Involved In Immune Response DNA Protection Response To Hydrogen Peroxide RNA Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Response To Temperature Stimulus Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Extracellular Stimulus Response To Tumor Cell Immunoglobulin Secretion Olfactory Placode Formation Cellular Response To Cold Spermatid Nucleus Elongation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Lens Induction In Camera-type Eye Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Energy Homeostasis Positive Regulation Of Cellular Metabolic Process Cellular Response To Nitric Oxide Response To Redox State Response To Nitric Oxide
Tagcloud ?			bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Difference) ?			bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
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