TXNDC17 and OXT

Number of citations of the paper that reports this interaction (PubMedID 14607844)
0

Data Source:
HPRD (in vitro)

		TXNDC17	OXT
Description		thioredoxin domain containing 17	oxytocin/neurophysin I prepropeptide
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Terminal Bouton Neuronal Dense Core Vesicle
	Molecular Function	Peroxidase Activity Protein Binding Protein-disulfide Reductase [NAD(P)H] Activity	Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding Oxytocin Receptor Binding
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Cellular Oxidant Detoxification	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Genistein Response To Prostaglandin E Social Behavior Intracellular Signal Transduction Negative Regulation Of Urine Volume Response To Cocaine Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Response To Steroid Hormone Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis
Pathways			Vasopressin-like receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Blood protein levels ( 30072576) Serum oxytocin levels ( 31361301)
Interacting Genes		9 interacting genes: AVP DYNLL1 EXOSC8 INCA1 INS OXT RUFY1 TINF2 TXNRD1	5 interacting genes: ESR2 KMT2A OXTR PREP TXNDC17
Entrez ID		84817	5020
HPRD ID		11656	08880
Ensembl ID		ENSG00000129235	ENSG00000101405
Uniprot IDs		A0A140VJY7 Q9BRA2	P01178 X5D7M6
PDB IDs		1WOU	7OFG 7OTD 7QVM 7RYC
Enriched GO Terms of Interacting Partners?		Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Grooming Behavior Positive Regulation Of Secretion Hormone Activity Positive Regulation Of Secretion By Cell Maternal Behavior Parental Behavior Secretory Granule Mating Behavior Neuronal Dense Core Vesicle Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Reproductive Behavior Identical Protein Binding Response To Electrical Stimulus Regulation Of Secretion By Cell Regulation Of Secretion Social Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding NADPH Peroxidase Activity Positive Regulation Of Transport Regulation Of Amine Transport V1A Vasopressin Receptor Binding Regulation Of Transport Negative Regulation Of Glycogen Catabolic Process Regulation Of Hindgut Contraction Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Perinucleolar Chromocenter Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Penile Erection Positive Regulation Of Norepinephrine Secretion Positive Regulation Of Female Receptivity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Cell Growth Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance	Nuclear Estrogen Receptor Activity T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Maternal Process Involved In Parturition Vasopressin Receptor Activity Oxytocin Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Vasopressin Oligopeptidase Activity Protein-disulfide Reductase [NAD(P)H] Activity Estrogen Response Element Binding
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