TXNDC17 and OXT

Number of citations of the paper that reports this interaction (PMID 14607844)
12

Data Source:
HPRD (in vitro)

		TXNDC17	OXT
Gene Name		thioredoxin domain containing 17	oxytocin/neurophysin I prepropeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Secretory Granule Terminal Bouton
	Molecular Function	Peroxidase Activity Protein Binding Electron Carrier Activity Protein-disulfide Reductase Activity	Neurohypophyseal Hormone Activity Oxytocin Receptor Binding
	Biological Process	Tumor Necrosis Factor-mediated Signaling Pathway Oxidation-reduction Process	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Sleep Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Prostaglandin E Social Behavior Negative Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Cocaine Hyperosmotic Salinity Response Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Uterine Smooth Muscle Contraction
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Oxytocin
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AVP DYNLL1 EXOSC8 INS OXT RUFY1 TINF2 TXNRD1	5 interactors: ESR2 KMT2A OXTR PREP TXNDC17
Entrez ID		84817	5020
HPRD ID		11656	08880
Ensembl ID		ENSG00000129235	ENSG00000101405
Uniprot IDs		Q9BRA2	P01178
PDB IDs		1WOU
Enriched GO Terms of Interacting Partners?		Maternal Aggressive Behavior Hyperosmotic Salinity Response Aggressive Behavior Regulation Of Cellular Component Organization Regulation Of Female Receptivity Maternal Behavior Female Mating Behavior Grooming Behavior Regulation Of Renal Sodium Excretion Copulation Hyperosmotic Response Regulation Of Excretion Homeostatic Process Mating Behavior Positive Regulation Of Transport Response To Salt Stress Positive Regulation Of Blood Pressure Social Behavior Positive Regulation Of Secretion Mating Regulation Of Organelle Organization Regulation Of Neurological System Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Hindgut Contraction Regulation Of Fatty Acid Metabolic Process Response To Osmotic Stress Regulation Of Mitochondrion Organization Renal System Process Regulation Of Protein ADP-ribosylation Negative Regulation Of Glycogen Catabolic Process Regulation Of Hindgut Contraction Ion Homeostasis Positive Regulation Of Cell Growth Regulation Of DNA Replication Regulation Of Lipid Biosynthetic Process Regulation Of Anion Transport Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Secretion Positive Regulation Of DNA Metabolic Process Response To Alkaloid Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Regulation Of Ion Homeostasis Positive Regulation Of Cellular PH Reduction Positive Regulation Of Norepinephrine Secretion	Positive Regulation Of Cellular Response To Drug Response To Anoxia Positive Regulation Of Norepinephrine Secretion Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Negative Regulation Of Gastric Acid Secretion Regulation Of Response To Drug Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Gastric Acid Secretion Regulation Of Systemic Arterial Blood Pressure By Vasopressin Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Penile Erection Sperm Ejaculation Maternal Process Involved In Parturition Rhythmic Process Regulation Of Penile Erection Positive Regulation Of Catecholamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Histone H3-K4 Trimethylation Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Synaptic Transmission, GABAergic Sleep Maternal Behavior Histone H4-K16 Acetylation Vagina Development Positive Regulation Of Histone H3-K4 Methylation Insemination Uterus Development ERK1 And ERK2 Cascade Parturition Intracellular Estrogen Receptor Signaling Pathway Epithelial Cell Differentiation Involved In Prostate Gland Development Response To Steroid Hormone Extracellular Negative Regulation Of Signal Transduction Gland Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Organic Substance Copulation Epithelial Cell Maturation Suckling Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Female Genitalia Development Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Negative Regulation Of Receptor Activity Positive Regulation Of Smooth Muscle Contraction Cellular Response To Hormone Stimulus Peptidyl-lysine Trimethylation
Tagcloud ?			altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus
Tagcloud (Difference) ?			altering anorexigenic arcuate basel broader dmnv fos hyperphagia hypothalamus icv immunoreactive intake intraperitoneal ip islets karger locomotor medulla nasal nts oxytocin paraventricular postrema potentiated pvn route solitary tolerance vagus
Tagcloud (Intersection) ?