ORAI2 and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ORAI2	UNC119
Gene Name		ORAI calcium release-activated calcium modulator 2	unc-119 homolog (C. elegans)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Growth Cone	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Binding	Protein Binding Lipid Binding
	Biological Process		Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: COPS6 GDF9 MED31 SETDB1 UNC119	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		80228	9094
HPRD ID		09860	04927
Ensembl ID		ENSG00000160991	ENSG00000109103
Uniprot IDs		B4DUB4 Q96SN7	Q13432
PDB IDs			3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-mediated Endocytosis Oocyte Growth Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Progesterone Secretion Regulation Of Caveolin-mediated Endocytosis Developmental Growth Mitotic Cytokinetic Process Cullin Deneddylation Histone H3-K9 Trimethylation Protein Deneddylation Regulation Of Clathrin-mediated Endocytosis Regulation Of Female Gonad Development Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Growth Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Peptidyl-lysine Trimethylation Blastocyst Growth	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
Tagcloud ?		200nm ae aminoethoxydiphenyl apb blocker blocks borinate ca2 coupling dimeric dpb162 f394h generates infer narrowed orai1 orai3 potently pumps restores slowly soar stim stim1 stim2 store trpc uncoupler
Tagcloud (Difference) ?		200nm ae aminoethoxydiphenyl apb blocker blocks borinate ca2 coupling dimeric dpb162 f394h generates infer narrowed orai1 orai3 potently pumps restores slowly soar stim stim1 stim2 store trpc uncoupler
Tagcloud (Intersection) ?