ORAI2 and MED31

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ORAI2	MED31
Gene Name		ORAI calcium release-activated calcium modulator 2	mediator complex subunit 31
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Growth Cone	Nucleoplasm Mediator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding Protein Complex Binding
	Biological Process		Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: COPS6 GDF9 MED31 SETDB1 UNC119	58 interactors: AES AGR2 ANXA7 ASCC2 C2orf44 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 UBE2B ZBTB45 ZSCAN1
Entrez ID		80228	51003
HPRD ID		09860	14382
Ensembl ID		ENSG00000160991	ENSG00000108590
Uniprot IDs		B4DUB4 Q96SN7	Q9Y3C7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-mediated Endocytosis Oocyte Growth Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Progesterone Secretion Regulation Of Caveolin-mediated Endocytosis Developmental Growth Mitotic Cytokinetic Process Cullin Deneddylation Histone H3-K9 Trimethylation Protein Deneddylation Regulation Of Clathrin-mediated Endocytosis Regulation Of Female Gonad Development Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Growth Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Peptidyl-lysine Trimethylation Blastocyst Growth	Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Developmental Process Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Differentiation Multicellular Organismal Development Response To Stimulus Neurotransmitter Uptake Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Telomere Maintenance Via Semi-conservative Replication System Development Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Cell Death Telomere Maintenance Via Recombination Nuclear DNA Replication Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Embryo Development Ending In Birth Or Egg Hatching DNA-templated Transcription, Initiation Response To External Stimulus Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		200nm ae aminoethoxydiphenyl apb blocker blocks borinate ca2 coupling dimeric dpb162 f394h generates infer narrowed orai1 orai3 potently pumps restores slowly soar stim stim1 stim2 store trpc uncoupler
Tagcloud (Difference) ?		200nm ae aminoethoxydiphenyl apb blocker blocks borinate ca2 coupling dimeric dpb162 f394h generates infer narrowed orai1 orai3 potently pumps restores slowly soar stim stim1 stim2 store trpc uncoupler
Tagcloud (Intersection) ?