MUS81 and CHEK2

Number of citations of the paper that reports this interaction (PMID 11073977)
112

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MUS81	CHEK2
Gene Name		MUS81 structure-specific endonuclease subunit	checkpoint kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Repair DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		5 interactors: CHEK2 EME1 EME2 SLX1A SLX4	47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID		80198	11200
HPRD ID		09419	05084
Ensembl ID		ENSG00000172732	ENSG00000183765
Uniprot IDs		Q53ES5 Q96NY9	O96017
PDB IDs		2MC3 2ZIX	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleic Acid Phosphodiester Bond Hydrolysis Response To Intra-S DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Double-strand Break Repair DNA Catabolic Process, Exonucleolytic Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Signal Transduction Involved In Intra-S DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Catabolic Process Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Nuclear Cell Cycle DNA Replication Intra-S DNA Damage Checkpoint DNA Damage Induced Protein Phosphorylation Aromatic Compound Catabolic Process Replicative Senescence Catabolic Process Mitotic Spindle Assembly Response To Stimulus Mitotic Spindle Organization Response To Biotic Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Cell Aging Spindle Assembly Protein Stabilization Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint	Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		adjacent analyze chinese clinicopathological colorectal correlated correlation correlations corresponding distant explore han marker markers metastasis nested normal parameters pattern profile progression quantitative real stage suggesting tissues tnm tumor value	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?