MUS81 and EME2

Number of citations of the paper that reports this interaction (PubMedID 17289582)
0

Data Source:
BioGRID (pull down)

		MUS81	EME2
Description		MUS81 structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease subunit 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex	Chromosome, Telomeric Region Nucleus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters Metal Ion Binding 3'-flap Endonuclease Activity	DNA Binding Nuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Enzyme-substrate Adaptor Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Break-induced Replication DNA Repair Double-strand Break Repair DNA Catabolic Process DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Osteoblast Proliferation Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	5 interacting genes: FAAP24 FANCM MEOX2 MUS81 UBC
Entrez ID		80198	197342
HPRD ID		09419	16859
Ensembl ID		ENSG00000172732	ENSG00000197774
Uniprot IDs		Q53ES5 Q96NY9	A4GXA9
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S 6VWB 7BU5 7F6L 9F98 9F99 9F9A 9F9K 9F9L 9F9M	7F6L
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA Recombination Holliday Junction Resolvase Complex Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Nucleic Acid Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Meiotic Recombination Intermediates DNA Damage Checkpoint Signaling Telomere Maintenance Nucleobase-containing Compound Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Slx1-Slx4 Complex Signal Transduction In Response To DNA Damage Positive Regulation Of T-circle Formation Response To Intra-S DNA Damage Checkpoint Signaling Endodeoxyribonuclease Complex Response To Stress Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Resolution Of Mitotic Recombination Intermediates Negative Regulation Of Cell Cycle Phase Transition Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Mitotic DNA Damage Checkpoint Signaling Organelle Organization Meiosis I Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Telomeric D-loop Disassembly Resolution Of DNA Recombination Intermediates Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Nucleoplasm Telomeric Loop Disassembly Spindle Assembly T-circle Formation Regulation Of Cell Cycle Process PML Body Chromosome Organization Negative Regulation Of Cell Cycle Nuclease Activity Regulation Of Protein Catabolic Process Nucleus	FANCM-MHF Complex Fanconi Anaemia Nuclear Complex Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Interstrand Cross-link Repair Meiosis I Cell Cycle Process DNA Repair DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Nuclease Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process DNA Binding Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Damage Response Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Somite Specification Positive Regulation Of Protein Monoubiquitination Resolution Of Mitotic Recombination Intermediates Four-way Junction Helicase Activity Double-strand Break Repair Regulation Of Protein Monoubiquitination DNA Recombination Response To DNA Damage Checkpoint Signaling Chromatin Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Osteoblast Proliferation Double-strand Break Repair Via Break-induced Replication 3'-5' DNA Helicase Activity Protein Tag Activity Segment Specification Somite Development Four-way Junction DNA Binding Mitotic Intra-S DNA Damage Checkpoint Signaling Nuclear Replication Fork Cellular Response To Stress DNA Endonuclease Activity Nucleus Chromatin Binding DNA Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Replication Fork Homologous Recombination Nucleoplasm
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