MUS81 and SLX1A

Number of citations of the paper that reports this interaction (PubMedID 19596236)
65

Data Source:
BioGRID (pull down)

		MUS81	SLX1A
Description		MUS81 structure-specific endonuclease subunit	structure-specific endonuclease subunit SLX1A
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex	Nucleus Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters Metal Ion Binding 3'-flap Endonuclease Activity	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Break-induced Replication DNA Repair Double-strand Break Repair DNA Catabolic Process DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Osteoblast Proliferation Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		80198	548593
HPRD ID		09419	18681
Ensembl ID		ENSG00000172732	ENSG00000132207
Uniprot IDs		Q53ES5 Q96NY9	Q9BQ83
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S 6VWB 7BU5 7F6L 9F98 9F99 9F9A 9F9K 9F9L 9F9M
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA Recombination Holliday Junction Resolvase Complex Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Nucleic Acid Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Meiotic Recombination Intermediates DNA Damage Checkpoint Signaling Telomere Maintenance Nucleobase-containing Compound Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Slx1-Slx4 Complex Signal Transduction In Response To DNA Damage Positive Regulation Of T-circle Formation Response To Intra-S DNA Damage Checkpoint Signaling Endodeoxyribonuclease Complex Response To Stress Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Resolution Of Mitotic Recombination Intermediates Negative Regulation Of Cell Cycle Phase Transition Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Mitotic DNA Damage Checkpoint Signaling Organelle Organization Meiosis I Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Telomeric D-loop Disassembly Resolution Of DNA Recombination Intermediates Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Nucleoplasm Telomeric Loop Disassembly Spindle Assembly T-circle Formation Regulation Of Cell Cycle Process PML Body Chromosome Organization Negative Regulation Of Cell Cycle Nuclease Activity Regulation Of Protein Catabolic Process Nucleus	Resolution Of Meiotic Recombination Intermediates ERCC4-ERCC1 Complex Telomere Maintenance Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Telomere Organization Response To DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Recombination Meiosis I Cell Cycle Process DNA Damage Response Chromosome Organization DNA Repair Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Nucleotide-excision Repair Positive Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Cellular Response To Stress Endodeoxyribonuclease Complex DNA Metabolic Process Resolution Of Mitotic Recombination Intermediates Nucleotide-excision Repair Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Capping Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Telomere Maintenance T-circle Formation UV Protection Nuclease Activity Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Double-strand Break Repair Via Homologous Recombination Organelle Organization Recombinational Repair Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Reproductive Process Mitotic Recombination Nuclear Replication Fork Cellular Response To Radiation DNA Endonuclease Activity
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