MUS81 and SLX4

Number of citations of the paper that reports this interaction (PubMedID 19596236)
65

Data Source:
HPRD (in vivo)

		MUS81	SLX4
Description		MUS81 structure-specific endonuclease subunit	SLX4 structure-specific endonuclease subunit
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters Metal Ion Binding 3'-flap Endonuclease Activity	DNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Break-induced Replication DNA Repair Double-strand Break Repair DNA Catabolic Process DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Osteoblast Proliferation Resolution Of Mitotic Recombination Intermediates Response To Intra-S DNA Damage Checkpoint Signaling	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)	Type 2 diabetes ( 32499647)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	9 interacting genes: APP EME1 ERCC4 ERG MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		80198	84464
HPRD ID		09419	12537
Ensembl ID		ENSG00000172732	ENSG00000188827
Uniprot IDs		Q53ES5 Q96NY9	Q8IY92
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S 6VWB 7BU5 7F6L 9F98 9F99 9F9A 9F9K 9F9L 9F9M	4M7C 4UYI 4ZOU 7BU5 7TUJ
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA Recombination Holliday Junction Resolvase Complex Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Nucleic Acid Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Meiotic Recombination Intermediates DNA Damage Checkpoint Signaling Telomere Maintenance Nucleobase-containing Compound Metabolic Process Telomere Organization Negative Regulation Of DNA Metabolic Process Slx1-Slx4 Complex Signal Transduction In Response To DNA Damage Positive Regulation Of T-circle Formation Response To Intra-S DNA Damage Checkpoint Signaling Endodeoxyribonuclease Complex Response To Stress Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Macromolecule Metabolic Process Resolution Of Mitotic Recombination Intermediates Negative Regulation Of Cell Cycle Phase Transition Response To DNA Damage Checkpoint Signaling DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Mitotic DNA Damage Checkpoint Signaling Organelle Organization Meiosis I Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Telomeric D-loop Disassembly Resolution Of DNA Recombination Intermediates Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Nucleoplasm Telomeric Loop Disassembly Spindle Assembly T-circle Formation Regulation Of Cell Cycle Process PML Body Chromosome Organization Negative Regulation Of Cell Cycle Nuclease Activity Regulation Of Protein Catabolic Process Nucleus	Crossover Junction DNA Endonuclease Activity Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Nuclease Activity Telomere Organization Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Resolution Of Mitotic Recombination Intermediates Double-strand Break Repair Response To DNA Damage Checkpoint Signaling DNA Recombination Meiosis I Cell Cycle Process Endonuclease Activity Resolution Of DNA Recombination Intermediates Nucleoplasm Chromosome Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleus Nuclear Replication Fork Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Endonuclease Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Mitotic Cell Cycle DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Replication Fork Processing Negative Regulation Of Cell Cycle Phase Transition Regulation Of Telomere Maintenance Via Telomere Lengthening DNA Binding Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Chaperone-mediated Autophagy DNA Metabolic Process SUMO Conjugating Enzyme Activity DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle
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