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ARHGEF5 and CALCOCO2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
ARHGEF5
CALCOCO2
Description
Rho guanine nucleotide exchange factor 5
calcium binding and coiled-coil domain 2
Image
No pdb structure
GO Annotations
Cellular Component
Podosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell Projection
Anchoring Junction
Cell Periphery
Autophagosome Membrane
Nucleus
Cytoplasm
Autophagosome
Cytosol
Cytoskeleton
Membrane
PML Body
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
Lipid Binding
Protein Binding
Zinc Ion Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Myeloid Dendritic Cell Chemotaxis
Actin Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of GTPase Activity
Positive Regulation Of JUN Kinase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cytoskeleton Organization
Positive Regulation Of Stress Fiber Assembly
Hematopoietic Stem Cell Homeostasis
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Podosome Assembly
Positive Regulation Of Protein Import
Autophagy
Viral Process
Response To Type II Interferon
Xenophagy
Positive Regulation Of Autophagosome Maturation
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOG GTPase cycle
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
Breast cancer, ovarian cancer or prostate cancer (pleiotropy) (
27432226
)
Gut microbiota relative abundance (Parabacteroides) (
33208821
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Chronotype (
30696823
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Serum alkaline phosphatase levels (
33547301
)
Type 2 diabetes (
29358691
29632382
)
Type 2 diabetes (adjusted for BMI) (
29632382
)
Interacting Genes
28 interacting genes:
APP
ATP13A1
CALCOCO2
CCNE1
CHPF
COG6
EFHC2
EPM2AIP1
FKBP8
HSF2BP
HSPBAP1
LMO2
LRATD1
MB21D2
MID2
NR4A1
PICK1
PLCG1
PLEKHG4
POLR1C
RHOA
SEPHS2
SLAIN1
TBC1D13
TCF4
TRIM27
TRIM54
ZRANB1
182 interacting genes:
ABLIM1
ADSL
AMMECR1
AP5B1
APEX2
ARHGEF39
ARHGEF5
ARNT2
ATG5
ATOSB
AXIN1
BAHD1
BCL6B
CBX8
CCDC120
CCDC185
CCDC33
CCNH
CDC7
CELA2B
CEP57L1
CHCHD3
CNNM3
CPNE7
CWF19L2
DAXX
DAZAP2
DBNDD2
DCTN4
DCX
DDIT4L
DDX6
DOCK2
DUSP12
DUSP26
EEF1E1
EFHC1
ELOA2
ENKD1
ENTREP1
EXOSC5
FAM107A
FAM161A
FAM168A
FAM90A1
FARS2
FASTK
FBF1
FBXL18
FKBPL
FMR1
FNDC11
FOXD4L3
FUBP3
FXR2
GABARAPL1
GABARAPL2
GATAD2B
GCA
GEMIN4
GIT2
GLYCTK
HDAC4
HDAC7
HLX
HNRNPA1
HNRNPK
HNRNPLL
HOXB5
HOXB9
IL16
IQUB
KANSL1
KAT7
KLHL35
KLHL42
LENG1
LGALS8
LIMS2
LITAF
LMF2
LMO2
LMO4
LNX1
LONRF1
LSM4
MAGOHB
MAP1LC3C
MCM10
METTL17
MID2
MOS
MTPAP
MVP
MXI1
MYH6
MYO6
NAA10
NDN
NFU1
ORC5
PCGF1
PEF1
PEG10
PFDN5
PHF1
PIAS4
POLI
POLR2A
PPP1R18
PRKAA2
PRKAB2
PRPF18
PRPF31
PSMA1
PSME4
PTBP1
PTBP2
RAB35
RABL6
RB1CC1
RBM15
RHPN1
RIN1
RNF11
RPA2
RPL9
RPS27A
RTN4IP1
RTP5
RXRB
SCAND1
SCNM1
SDCBP
SETD5
SHC1
SLC15A3
SMARCD1
SMCP
SNRPB
SPATA24
SRI
STAMBPL1
STK16
TACO1
TBC1D22B
TBRG4
TCL1A
TEKT3
TENT2
TLE5
TNFAIP3
TP53RK
TRAF2
TRAF4
TSC1
TSGA10IP
TTC23L
UBAC2
UBC
ULK1
USP2
VARS1
VPS72
WWP2
ZBTB4
ZC2HC1C
ZNF101
ZNF205
ZNF337
ZNF408
ZNF414
ZNF426
ZNF451
ZNF564
ZNF581
ZNF638
ZNF648
ZNF688
ZNF696
ZNF774
ZNF80
Entrez ID
7984
10241
HPRD ID
02932
06846
Ensembl ID
ENSG00000050327
ENSG00000136436
Uniprot IDs
Q12774
Q13137
PDB IDs
2MXP
3VVV
3VVW
4GXL
4HAN
4XKL
5AAQ
5Z7A
5Z7L
7EAA
Enriched GO Terms of Interacting Partners
?
Regulation Of Supramolecular Fiber Organization
Cytoplasm
Protein Binding
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Zinc Ion Binding
Cellular Response To Nitrogen Starvation
Ubiquitin Protein Ligase Binding
MRNA Processing
MRNA Metabolic Process
MRNA Binding
Regulation Of RNA Splicing
Cytoplasm
RNA Splicing
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
RNA Metabolic Process
Metal Ion Binding
Regulation Of Transcription By RNA Polymerase II
DNA Binding
Chromatin Organization
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Cellular Response To Nutrient Levels
RNA Processing
Macromolecule Metabolic Process
Response To Starvation
Autophagy Of Mitochondrion
Spliceosomal Complex
Epigenetic Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Nuclear Speck
Regulation Of MRNA Metabolic Process
Autophagosome
Autophagosome Membrane
Negative Regulation Of Metabolic Process
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
SnRNP Binding
Mitophagy
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Phosphatidylethanolamine Binding
Negative Regulation Of Gene Expression
Cytoplasmic Stress Granule
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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