ARHGEF5 and CHPF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ARHGEF5	CHPF
Description		Rho guanine nucleotide exchange factor 5	chondroitin polymerizing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Matrix Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding Acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	CS-GAG biosynthesis
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	11 interacting genes: ARHGEF5 BTRC EXOSC10 EXOSC6 LCOR LINC00839 NKX3-1 PIN1 PRKN SKIL SMAD9
Entrez ID		7984	79586
HPRD ID		02932	10829
Ensembl ID		ENSG00000050327	ENSG00000123989
Uniprot IDs		Q12774	Q8IZ52
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization Cytoplasm	Ubiquitin Ligase Activator Activity Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing Nuclear MRNA Surveillance Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Beta-catenin Binding Ubiquitin-specific Protease Binding Regulation Of Dopamine Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Histone Deacetylase Binding Protein K6-linked Ubiquitination Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nuclear Estrogen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway MADS Box Domain Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Regulation Of Protein Targeting To Mitochondrion Cis-trans Isomerase Activity RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Regulation Of Primary Metabolic Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Dorsal Aorta Development Positive Regulation Of Retrograde Transport, Endosome To Golgi SCF Ubiquitin Ligase Complex Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?