ARHGEF5 and LRATD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF5	LRATD1
Description		Rho guanine nucleotide exchange factor 5	LRAT domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Cell Morphogenesis Cell Motility
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	2 interacting genes: ARHGEF5 CYGB
Entrez ID		7984	151354
HPRD ID		02932	17647
Ensembl ID		ENSG00000050327	ENSG00000162981
Uniprot IDs		Q12774	Q96KN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization Cytoplasm	Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Catalase Activity Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Carbon Monoxide Binding Superoxide Dismutase Activity Nitrite Reductase Activity Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Dendritic Cell Chemotaxis Positive Regulation Of JUN Kinase Activity Negative Regulation Of Collagen Biosynthetic Process Oxygen Carrier Activity Removal Of Superoxide Radicals Oxygen Transport Negative Regulation Of Fibroblast Migration Dendritic Cell Migration Antioxidant Activity Hematopoietic Stem Cell Homeostasis Oxygen Binding Nitric Oxide Metabolic Process Peroxidase Activity Reactive Nitrogen Species Metabolic Process Positive Regulation Of MAP Kinase Activity Podosome Regulation Of Fibroblast Migration Regulation Of Collagen Biosynthetic Process Superoxide Metabolic Process Regulation Of Collagen Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Actin Filament Bundle Assembly Regulation Of MAP Kinase Activity Cellular Oxidant Detoxification Fatty Acid Oxidation Lipid Oxidation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?