ARHGEF5 and HSPBAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ARHGEF5	HSPBAP1
Description		Rho guanine nucleotide exchange factor 5	HSPB1 associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding 2-oxoglutarate-dependent Dioxygenase Activity
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	5 interacting genes: ARHGEF5 NUTM1 PTN RIPK3 TK1
Entrez ID		7984	79663
HPRD ID		02932	12197
Ensembl ID		ENSG00000050327	ENSG00000169087
Uniprot IDs		Q12774	A8K045 Q96EW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization Cytoplasm	Leukocyte Chemotaxis Dendrite Regeneration Ossification Involved In Bone Remodeling DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Positive Regulation Of DNA-binding Transcription Factor Activity Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Regulation Of Leukocyte Migration Cell Chemotaxis Leukocyte Migration Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Thymidine Metabolic Process Thymidine Biosynthetic Process Regulation Of Protein Kinase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Homeostasis Of Number Of Cells Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Necroptotic Process Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Axon Regeneration Deoxyribonucleoside Monophosphate Biosynthetic Process Necroptotic Signaling Pathway Dendrite Arborization Negative Regulation Of Long-term Synaptic Potentiation Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Estrous Cycle Chemotaxis Positive Regulation Of Podosome Assembly Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Neuroblast Proliferation Pyrimidine Nucleoside Metabolic Process Locomotion Regulation Of Podosome Assembly Regulation Of Hepatocyte Proliferation Positive Regulation Of Dendrite Development Necroptotic Process Positive Regulation Of Protein Modification Process
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