ARHGEF5 and TBC1D13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF5	TBC1D13
Description		Rho guanine nucleotide exchange factor 5	TBC1 domain family member 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery	Cytoplasm Cytosol Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Intracellular Protein Transport Regulation Of Cilium Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	TBC/RABGAPs
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)	Blood metabolite levels ( 26401656) HDL cholesterol levels ( 32203549) Serum metabolite levels ( 33031748)
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	5 interacting genes: ARHGEF5 PLIN3 SPDYE4 TEPSIN ZNF618
Entrez ID		7984	54662
HPRD ID		02932	18163
Ensembl ID		ENSG00000050327	ENSG00000107021
Uniprot IDs		Q12774	A0A024R8C8 B3KNG3 B4DHM6 Q9NVG8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization Cytoplasm	Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Positive Regulation Of Triglyceride Storage Coated Vesicle Membrane
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