ARHGEF5 and MB21D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF5	MB21D2
Description		Rho guanine nucleotide exchange factor 5	Mab-21 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding Transferase Activity Nucleotidyltransferase Activity Protein-containing Complex Binding Cadherin Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)	Anti-saccade response ( 29064472)
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	13 interacting genes: ARHGEF5 ATXN7L2 BYSL CBX8 CIRSR DTNB EVI5 MORN3 RAB3IP REL SLC12A4 SPRY1 SPRY2
Entrez ID		7984	151963
HPRD ID		02932	14092
Ensembl ID		ENSG00000050327	ENSG00000180611
Uniprot IDs		Q12774	Q8IYB1
PDB IDs			7LT1
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization Cytoplasm	Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium Axis Elongation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Ras Protein Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Establishment Of Spindle Localization ERK1 And ERK2 Cascade Spindle Localization Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Import Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Lung Growth Ciliary Basal Body-plasma Membrane Docking Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development
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