ARHGEF5

Name	Rho guanine nucleotide exchange factor 5
Structure	No pdb structure
Novel Interactors	1 novel interactors: SLU7
Interactors	28 interactors: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import
Pathways	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
GWAS	Breast cancer ( 23535729 ) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Gut microbiota relative abundance (Parabacteroides) ( 33208821 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )
Entrez ID	7984
HPRD ID	02932
Ensembl ID	ENSG00000050327
Uniprot IDs	Q12774
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Supramolecular Fiber Organization Cytoplasm