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SUV39H2 and APPL2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid, two hybrid)
SUV39H2
APPL2
Description
SUV39H2 histone lysine methyltransferase
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Chromatin
Nucleus
Nucleoplasm
Chromosome
Ruffle
Nucleus
Cytoplasm
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Cytoplasmic Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Vesicle
Early Phagosome
Ruffle Membrane
Early Phagosome Membrane
Cell Projection
Macropinosome
Phagocytic Vesicle
Extracellular Exosome
Bounding Membrane Of Organelle
Molecular Function
Transcription Cis-regulatory Region Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Histone Methyltransferase Activity
Metal Ion Binding
Histone H3K9 Methyltransferase Activity
Histone H3 Methyltransferase Activity
Histone H3K9 Trimethyltransferase Activity
S-adenosyl-L-methionine Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Phosphatidylserine Binding
Protein Binding
Phosphatidylinositol Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Circadian Rhythm
Cell Differentiation
Methylation
Epigenetic Programming In The Zygotic Pronuclei
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Cellular Response To Hypoxia
Diet Induced Thermogenesis
Protein Import Into Nucleus
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Cold Acclimation
Regulation Of Fibroblast Migration
Signaling
Adiponectin-activated Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Homeostatic Process
Glucose Homeostasis
Regulation Of Innate Immune Response
Negative Regulation Of Fatty Acid Oxidation
Negative Regulation Of D-glucose Import
Negative Regulation Of Neurogenesis
Protein Homotetramerization
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Cellular Response To Insulin Stimulus
Positive Regulation Of Macropinocytosis
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Neural Precursor Cell Proliferation
Pathways
PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Mosquito bite size (
28199695
)
Interacting Genes
43 interacting genes:
AKAP9
APPL2
AR
BLZF1
C8orf74
CBX7
CDCA4
CEP70
CFAP100
CGGBP1
EWSR1
FAM20C
GOLGA6L9
GSTCD
H3C1
ID2
KCTD17
KLF3
KLHDC4
LCA5L
LNX1
LRIF1
MAGEA11
MCM3AP
MRFAP1
MTF2
MYL12A
NME4
ODAD3
PHF19
PNMA1
POLR3F
RAB3IP
RASSF1
SHC1
SMAD5
SNF8
UBE2V2
VHL
WIZ
ZNF212
ZNF557
ZNF57
31 interacting genes:
APPL1
ATF3
CNMD
CRADD
CRBN
CRLF3
CRYAA
DOK3
EPM2AIP1
HUNK
KIFC3
KMT2C
LDHAL6B
LGALS9C
LINC02875
LIX1
MLST8
MTA2
PINK1
POT1
PRR35
RAB22A
RAB5A
RAB5C
RAI2
RBBP7
RBP7
RUVBL2
SUV39H2
TINF2
TSC1
Entrez ID
79723
55198
HPRD ID
07580
06945
Ensembl ID
ENSG00000152455
ENSG00000136044
Uniprot IDs
Q9H5I1
Q8NEU8
PDB IDs
2R3A
6P0R
4H8S
5C5B
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Protein Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Histone H3K36me3 Reader Activity
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Telomere Assembly
Regulation Of Cellular Component Organization
Response To Oxygen Levels
Response To Decreased Oxygen Levels
Plasma Membrane To Endosome Transport
GDP Binding
Early Phagosome
NuRD Complex
Chromosome, Telomeric Region
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Positive Regulation Of Telomere Maintenance
Regulation Of DNA Strand Elongation
Nuclear Telomere Cap Complex
Shelterin Complex
Telomere Capping
Protein Kinase B Binding
TORC2 Signaling
Protein Binding
Regulation Of Vesicle Size
Phagocytic Vesicle
TOR Signaling
Negative Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Cell Fate Specification
Positive Regulation Of Cellular Component Organization
Telomere Maintenance
Protein Stabilization
Ruffle
Negative Regulation Of Autophagy
Positive Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
Regulation Of Cellular Component Size
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Endomembrane System
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Memory T Cell Differentiation
Protein Folding Chaperone Complex
Epigenetic Programming Of Gene Expression
Telomere Organization
Positive Regulation Of DNA Strand Elongation
Positive Regulation Of Telomeric D-loop Disassembly
G-rich Single-stranded DNA Binding
Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Generation Of Precursor Metabolites And Energy
Histone Methyltransferase Activity
Positive Regulation Of Biosynthetic Process
Response To Hypoxia
Negative Regulation Of Macroautophagy
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