SUV39H2 and KLHDC4

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SUV39H2	KLHDC4
Description		SUV39H2 histone lysine methyltransferase	kelch domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity S-adenosyl-L-methionine Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Circadian Rhythm Cell Differentiation Methylation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Hippocampal volume in mild cognitive impairment ( 29274321)
Interacting Genes		43 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD H3C1 ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 VHL WIZ ZNF212 ZNF557 ZNF57	8 interacting genes: CEP76 KDM1A MFHAS1 SUV39H1 SUV39H2 TERF1 TRIM55 TRIM63
Entrez ID		79723	54758
HPRD ID		07580	11180
Ensembl ID		ENSG00000152455	ENSG00000104731
Uniprot IDs		Q9H5I1	Q8TBB5
PDB IDs		2R3A 6P0R
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K36me3 Reader Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding	Histone H3K9 Trimethyltransferase Activity Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Histone H3 Methyltransferase Activity Telomeric DNA Binding Epigenetic Programming Of Gene Expression Histone Methyltransferase Activity Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of DNA Metabolic Process ENoSc Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Hypoxia Circadian Rhythm Cellular Response To Decreased Oxygen Levels Protein Demethylase Activity Chromosome, Centromeric Region Cellular Response To Oxygen Levels Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Methyltransferase Activity RDNA Heterochromatin Formation RDNA Heterochromatin Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Chromosome, Telomeric Region Innate Immune Response Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Response To Fungicide MRF Binding Guanine Metabolic Process Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Histone H3K9me2 Methyltransferase Activity
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