SUV39H2 and CBX7

Number of citations of the paper that reports this interaction (PubMedID 21060834)
35

Data Source:
BioGRID (protein complementation assay)

		SUV39H2	CBX7
Description		SUV39H2 histone lysine methyltransferase	chromobox 7
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome	Chromatin Nucleus Nucleoplasm Cytosol PcG Protein Complex PRC1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity S-adenosyl-L-methionine Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Circadian Rhythm Cell Differentiation Methylation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Lymphocyte count ( 27863252 32888494) Menarche (age at onset) ( 25231870) Multiple myeloma ( 23955597 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		43 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD H3C1 ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 VHL WIZ ZNF212 ZNF557 ZNF57	12 interacting genes: B3GNT5 H3-3A H3-4 H3C1 H3C14 PCGF1 PCGF5 PCGF6 RING1 RNF2 SUV39H2 ZRANB1
Entrez ID		79723	23492
HPRD ID		07580	12234
Ensembl ID		ENSG00000152455	ENSG00000100307
Uniprot IDs		Q9H5I1	B0QYP2 O95931 Q4PNR6
PDB IDs		2R3A 6P0R	2K1B 2L12 2L1B 3GS2 4MN3 5EPJ 6V2R 8SII
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K36me3 Reader Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding	Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex Structural Constituent Of Chromatin Nucleoplasm Nucleosome Assembly Epigenetic Regulation Of Gene Expression Nucleosome Nucleosome Organization Histone H2AK119 Ubiquitin Ligase Activity Chromosome Protein-DNA Complex Assembly Sex Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Activity Regulation Of Gene Expression Gene Expression Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Chromosome Condensation Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Spermatogonial Cell Division Protein K29-linked Deubiquitination Histone H3K9 Trimethyltransferase Activity X Chromosome Pericentric Heterochromatin Formation Telomere Organization Protein K33-linked Deubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Centromere Complex Assembly Heterochromatin Formation
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