TBL1XR1 and TBL1X

Number of citations of the paper that reports this interaction (PMID 21258344)
61

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		TBL1XR1	TBL1X
Gene Name		transducin (beta)-like 1 X-linked receptor 1	transducin (beta)-like 1X-linked
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Notch Signaling Pathway Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Proteolysis Notch Signaling Pathway Sensory Perception Of Sound Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression	Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Esophageal cancer ( 21642993)	Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: ARL2 CORO2A GPS2 HDAC3 HIST1H4F HIST2H2BE HIST2H4A NCOR1 TBL1X	25 interactors: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 GPS2 HDAC3 HIST1H4A HIST2H2AA3 HIST2H2BE HIST2H3C HIST2H4A HP HR KHDRBS1 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1
Entrez ID		79718	6907
HPRD ID		15476	02183
Ensembl ID		ENSG00000177565	ENSG00000101849
Uniprot IDs		Q9BZK7	O60907
PDB IDs			2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Organelle Organization Negative Regulation Of JNK Cascade Negative Regulation Of Stress-activated MAPK Cascade Protein Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Histone Modification DNA Methylation On Cytosine Nucleosome Assembly Chromatin Assembly Notch Signaling Pathway Chromatin Silencing At RDNA Cellular Component Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of MAPK Cascade Regulation Of Megakaryocyte Differentiation Regulation Of JNK Cascade Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging Regulation Of Stress-activated MAPK Cascade CENP-A Containing Nucleosome Assembly Cellular Macromolecular Complex Assembly Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Chromatin Silencing DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Protein Demethylation Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Conformation Change Centromere Complex Assembly DNA Methylation Histone Deacetylation Demethylation Protein Deacetylation ATP-dependent Chromatin Remodeling	Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Nucleobase-containing Compound Metabolic Process Lung Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Notch Signaling Pathway DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Telomere Maintenance Gene Expression Regulation Of Chromosome Organization Chromatin Modification Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Female Courtship Behavior DNA-templated Transcription, Initiation Organelle Organization Negative Regulation Of JNK Cascade Histone H4-K20 Demethylation Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Stress-activated MAPK Cascade Chromatin Silencing Transcription, DNA-templated Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Macromolecule Biosynthetic Process Lung Epithelial Cell Differentiation
Tagcloud ?		7ralpha aberrations abl1 bcp btg1 cofactors complemented concerted cooperating crlf2 deletions deregulated determinants drive e2a ebf1 hematological ikzf1 ink4a insufficient lineage lymphoblastic master overview pax5 prb runx1 specification translocations	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1
Tagcloud (Difference) ?		7ralpha aberrations abl1 bcp btg1 cofactors complemented concerted cooperating crlf2 deletions deregulated determinants drive e2a ebf1 hematological ikzf1 ink4a insufficient lineage lymphoblastic master overview pax5 prb runx1 specification translocations	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1
Tagcloud (Intersection) ?