TBL1XR1 and ARL2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		TBL1XR1	ARL2
Name		TBL1X/Y related 1	ARF like GTPase 2
Structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Lateral Plasma Membrane Ciliary Basal Body
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Response To Dietary Excess Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Lipid Catabolic Process Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Adipose Tissue Development Fat Pad Development Regulation Of Triglyceride Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Glycolytic Process Protein Folding Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly Regulation Of Aerobic Respiration
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing
GWAS		Asthma ( 34103634 32296059 31959851 31619474 30929738 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 30929738 ) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297 ) Central corneal thickness ( 31798171 32528159 29760442 ) Chin dimples ( 27182965 ) Chronotype ( 30696823 ) Corneal structure ( 23291589 ) Early chronic obstructive pulmonary disease in never smokers ( 33235445 ) Esophageal cancer ( 21642993 ) Inflammatory skin disease ( 25574825 ) Mastocytosis (KIT D816V positive) ( 33421400 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Pulse pressure ( 30224653 ) Red cell distribution width ( 32888494 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: POLA2
Interacting Genes		15 interacting genes: ARL2 CEBPA CORO2A DDB1 FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 OGT TBL1X UBE2I	7 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1X TBL1XR1 UNC119
Entrez ID		79718	402
HPRD ID		15476	11869
Ensembl ID		ENSG00000177565	ENSG00000213465
Uniprot IDs		C9JLJ1 Q9BZK7	P36404
PDB IDs		4LG9	3DOE 3DOF
GO Terms Enriched among Interactors		Transcription Repressor Complex Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Developmental Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of JNK Cascade Cellular Component Assembly Regulation Of Small Molecule Metabolic Process Histone Deacetylase Complex Nucleus Regulation Of Glycolytic Process Chromatin Remodeling Negative Regulation Of Cell Differentiation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II Rhythmic Process Transcription Cis-regulatory Region Binding Spindle Assembly Negative Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Glucose Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Metabolic Process Nucleosome Histone Deacetylase Binding Protein Heterodimerization Activity Nucleosome Organization Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Mitotic Spindle Regulation Of Nucleobase-containing Compound Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Transcription Repressor Complex Histone Deacetylase Complex Positive Regulation Of Peptidyl-tyrosine Phosphorylation Sensory Perception Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Peptidyl-tyrosine Phosphorylation Medial Motor Column Neuron Differentiation