TBL1XR1 and ARL2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TBL1XR1	ARL2
Gene Name		transducin (beta)-like 1 X-linked receptor 1	ADP-ribosylation factor-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex	Nucleus Mitochondrial Intermembrane Space Centrosome Lateral Plasma Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Notch Signaling Pathway Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway	Tubulin Complex Assembly Cell Cycle Small GTPase Mediated Signal Transduction Metabolic Process Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Centrosome Organization Maintenance Of Protein Location In Nucleus Tight Junction Assembly
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression	Protein folding Post-chaperonin tubulin folding pathway Orphan transporters
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Esophageal cancer ( 21642993)
Protein-Protein Interactions		9 interactors: ARL2 CORO2A GPS2 HDAC3 HIST1H4F HIST2H2BE HIST2H4A NCOR1 TBL1X	5 interactors: ARL2BP PDE6D TBCD TBL1XR1 UNC119
Entrez ID		79718	402
HPRD ID		15476	11869
Ensembl ID		ENSG00000177565	ENSG00000213465
Uniprot IDs		Q9BZK7	B4DGG0 P36404 Q53YD8
PDB IDs			3DOE 3DOF
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Organelle Organization Negative Regulation Of JNK Cascade Negative Regulation Of Stress-activated MAPK Cascade Protein Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Histone Modification DNA Methylation On Cytosine Nucleosome Assembly Chromatin Assembly Notch Signaling Pathway Chromatin Silencing At RDNA Cellular Component Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of MAPK Cascade Regulation Of Megakaryocyte Differentiation Regulation Of JNK Cascade Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging Regulation Of Stress-activated MAPK Cascade CENP-A Containing Nucleosome Assembly Cellular Macromolecular Complex Assembly Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Chromatin Silencing DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Protein Demethylation Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Conformation Change Centromere Complex Assembly DNA Methylation Histone Deacetylation Demethylation Protein Deacetylation ATP-dependent Chromatin Remodeling	Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Visual Perception Sensory Perception Of Light Stimulus Cytokinesis, Completion Of Separation Regulation Of Peptidyl-tyrosine Phosphorylation Post-chaperonin Tubulin Folding Pathway Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Positive Regulation Of Metabolic Process Regulation Of Clathrin-mediated Endocytosis Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Microtubule Polymerization Regulation Of Metabolic Process Maintenance Of Protein Location In Nucleus Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Microtubule Polymerization Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?		7ralpha aberrations abl1 bcp btg1 cofactors complemented concerted cooperating crlf2 deletions deregulated determinants drive e2a ebf1 hematological ikzf1 ink4a insufficient lineage lymphoblastic master overview pax5 prb runx1 specification translocations	attributed automata charged continuously diffusion electrostatic endomembranes endosome enrichment explains fitting geometries kinetic kras mislocalized pdedelta perinuclear phospholipids pm posttranslational prenylation proto realistic recycling relies restores sequestered unloaded vesicular
Tagcloud (Difference) ?		7ralpha aberrations abl1 bcp btg1 cofactors complemented concerted cooperating crlf2 deletions deregulated determinants drive e2a ebf1 hematological ikzf1 ink4a insufficient lineage lymphoblastic master overview pax5 prb runx1 specification translocations	attributed automata charged continuously diffusion electrostatic endomembranes endosome enrichment explains fitting geometries kinetic kras mislocalized pdedelta perinuclear phospholipids pm posttranslational prenylation proto realistic recycling relies restores sequestered unloaded vesicular
Tagcloud (Intersection) ?