TBL1XR1 and H2BC21

Number of citations of the paper that reports this interaction (PubMedID 15601853)
48

Data Source:
HPRD (in vitro)

		TBL1XR1	H2BC21
Description		TBL1X/Y related 1	H2B clustered histone 21
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Response To Dietary Excess Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Lipid Catabolic Process Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II White Fat Cell Differentiation Adipose Tissue Development Fat Pad Development Regulation Of Triglyceride Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Asthma ( 34103634 32296059 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Central corneal thickness ( 31798171 32528159 29760442) Chin dimples ( 27182965) Chronotype ( 30696823) Corneal structure ( 23291589) Early chronic obstructive pulmonary disease in never smokers ( 33235445) Esophageal cancer ( 21642993) Inflammatory skin disease ( 25574825) Mastocytosis (KIT D816V positive) ( 33421400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Pulse pressure ( 30224653) Red cell distribution width ( 32888494)
Interacting Genes		15 interacting genes: ARL2 CEBPA CORO2A DDB1 FOXK2 GPS2 H2BC21 H4C14 H4C6 HDAC3 MECP2 NCOR1 OGT TBL1X UBE2I	73 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NEIL3 NPM1 PARP10 PARP9 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMU1 SPANXN2 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1
Entrez ID		79718	8349
HPRD ID		15476	03494
Ensembl ID		ENSG00000177565	ENSG00000184678
Uniprot IDs		C9JLJ1 Q9BZK7	Q16778
PDB IDs		4LG9	4NFT 6A7U 6KBB 6M4D 6M4G 6M4H 7BXT 7EA8 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8H1T 8SPS 8SPU 8SYP 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8YJF
Enriched GO Terms of Interacting Partners?		Transcription Repressor Complex Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Developmental Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of JNK Cascade Cellular Component Assembly Regulation Of Small Molecule Metabolic Process Histone Deacetylase Complex Nucleus Regulation Of Glycolytic Process Chromatin Remodeling Negative Regulation Of Cell Differentiation DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of ATP Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of Transcription By RNA Polymerase II Rhythmic Process Transcription Cis-regulatory Region Binding Spindle Assembly Negative Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Glucose Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Nucleosome Assembly Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Metabolic Process Nucleosome Histone Deacetylase Binding Protein Heterodimerization Activity Nucleosome Organization Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Mitotic Spindle Regulation Of Nucleobase-containing Compound Metabolic Process Maintenance Of Protein Location In Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	Chromatin Organization Chromatin Remodeling Histone Binding Nucleoplasm Nucleus Protein Modification Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Macromolecule Metabolic Process Transferase Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K18 Acetyltransferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?