PLEKHF2 and HEY1

		PLEKHF2	HEY1
Description		pleckstrin homology and FYVE domain containing 2	hes related family bHLH transcription factor with YRPW motif 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Endosome Organization Endosome To Lysosome Transport Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Smooth Muscle Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Negative Regulation Of Biomineral Tissue Development Circulatory System Development Regulation Of Vasculogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Radiation response ( 20923822)	Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699)
Interacting Genes		168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581	22 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HUNK KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 OLIG2 PITX2 PLEKHB2 PRKD2 SKIL SMAD3 SMAD9 TENT5D TP53 YTHDF1
Entrez ID		79666	23462
HPRD ID		15147	04260
Ensembl ID		ENSG00000175895	ENSG00000164683
Uniprot IDs		Q9H8W4	B4DEI9 Q9Y5J3
PDB IDs			2DB7
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation	Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Lens Fiber Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Developmental Process Regulation Of Cell Population Proliferation Cellular Response To Actinomycin D Chromatin DNA Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BHLH Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Metabolic Process Response To Actinomycin D Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Antibiotic Cellular Response To UV-C Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression
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