HEY1 and YTHDF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HEY1	YTHDF1
Description		hes related family bHLH transcription factor with YRPW motif 1	YTH N6-methyladenosine RNA binding protein F1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	P-body Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Smooth Muscle Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Negative Regulation Of Biomineral Tissue Development Circulatory System Development Regulation Of Vasculogenesis	Immune System Process Regulation Of Antigen Processing And Presentation Learning Memory Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation MRNA Destabilization Organelle Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of Axon Guidance
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699)	Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		22 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HUNK KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 OLIG2 PITX2 PLEKHB2 PRKD2 SKIL SMAD3 SMAD9 TENT5D TP53 YTHDF1	42 interacting genes: ABHD11 BATF2 BICD2 C6orf15 CFTR CLK2 CPSF7 CTTN DMRTB1 DYNC1I1 ERI3 FAM168A FHIT HEY1 HSF4 ITSN2 KRTAP13-1 KRTAP26-1 KRTAP7-1 KRTAP8-1 LASP1 MAGED1 MOV10 MSX2 OIP5 PPIL3 PRR32 PRRC2B QKI RBFOX2 RBM22 RBMS3 RBPMS SARNP SF1 SNCA SNRPA TLE5 TMED9 VPS37C XRN2 ZNF34
Entrez ID		23462	54915
HPRD ID		04260	11691
Ensembl ID		ENSG00000164683	ENSG00000149658
Uniprot IDs		B4DEI9 Q9Y5J3	Q9BYJ9
PDB IDs		2DB7	4RCI 4RCJ 7PCU 7QKN 7QL7 7YYE 7YYF 7YYJ 7YZ8 8BS4
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Lens Fiber Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Developmental Process Regulation Of Cell Population Proliferation Cellular Response To Actinomycin D Chromatin DNA Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BHLH Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Metabolic Process Response To Actinomycin D Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Antibiotic Cellular Response To UV-C Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression	Nucleic Acid Binding MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome MRNA Metabolic Process Negative Regulation Of Biosynthetic Process RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Binding
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