HEY1 and FBXW7

Number of citations of the paper that reports this interaction (PMID 11585921)
71

Data Source:
HPRD (in vivo)

		HEY1	FBXW7
Gene Name		hes-related family bHLH transcription factor with YRPW motif 1	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Golgi Apparatus SCF Ubiquitin Ligase Complex Protein Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Protein Dimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Cyclin Binding Protein Binding, Bridging Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Vasculogenesis Osteoblast Development Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Anterior/posterior Axis Specification Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis	Vasculogenesis Vasculature Development Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Protein Localization Cellular Response To UV Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARNT FBXW7 GATA1 LAPTM5 MYOD1 PRKD2 SKIL SMAD3 SMAD9	33 interactors: ARL6IP1 CCNE1 CCNE2 CDC34 CREB3L1 CREB3L2 CUL1 EBNA1BP2 FAM101A GLMN GNB2L1 HEY1 HIPK2 JUN KIAA1875 KLF5 LINGO1 MCL1 MED13 MED13L MMS22L MYB MYC NOTCH1 NOTCH4 PARK2 PPARGC1A PSEN1 SHPRH SKP1 STOML1 SUMF2 UBE2D1
Entrez ID		23462	55294
HPRD ID		04260	05888
Ensembl ID		ENSG00000164683	ENSG00000109670
Uniprot IDs		Q9Y5J3	B7Z2C8 G0Z2K0 Q969H0 S4R3U4
PDB IDs		2DB7	2OVP 2OVQ 2OVR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Response To Abiotic Stimulus In Utero Embryonic Development Regulation Of Osteoblast Proliferation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Transcription, DNA-templated Lens Fiber Cell Differentiation Developmental Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Erythrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Communication Tube Development Response To Organic Substance Regulation Of Cell Proliferation	Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Notch Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Neuron Death Cellular Response To Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Ubiquitination Negative Regulation Of Neuron Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Cellular Response To Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Death Cell Cycle Phase Transition Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Gene Expression
Tagcloud ?		apocrine ar conclusiontogether crossed epithelium exclusively find gcdfp gland introductionperiostin mammary methodsusing mmtv neu notch null oncogene outgrowth periostin pip postn prolactin proliferate rescued resultsalthough stromal surprisingly transplanted wildtype	bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		apocrine ar conclusiontogether crossed epithelium exclusively find gcdfp gland introductionperiostin mammary methodsusing mmtv neu notch null oncogene outgrowth periostin pip postn prolactin proliferate rescued resultsalthough stromal surprisingly transplanted wildtype	bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?