HEY1 and LAPTM5

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HEY1	LAPTM5
Gene Name		hes-related family bHLH transcription factor with YRPW motif 1	lysosomal protein transmembrane 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Lysosome Lysosomal Membrane Integral Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Vasculogenesis Osteoblast Development Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Anterior/posterior Axis Specification Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis	Transport
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARNT FBXW7 GATA1 LAPTM5 MYOD1 PRKD2 SKIL SMAD3 SMAD9	25 interactors: ANKRD13A DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 HERC1 HEY1 HEYL HUWE1 ITCH KRT7 LDLRAD1 NEDD4 NEDD4L RNF168 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC USP13 WWP1
Entrez ID		23462	7805
HPRD ID		04260	03280
Ensembl ID		ENSG00000164683	ENSG00000162511
Uniprot IDs		Q9Y5J3	Q13571 Q5TBB8
PDB IDs		2DB7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Differentiation Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Response To Abiotic Stimulus In Utero Embryonic Development Regulation Of Osteoblast Proliferation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Transcription, DNA-templated Lens Fiber Cell Differentiation Developmental Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Erythrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Communication Tube Development Response To Organic Substance Regulation Of Cell Proliferation	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Notch Signaling Pathway Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Negative Regulation Of Signaling Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Monoubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Viral Life Cycle Regulation Of ERBB Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Catabolic Process Cellular Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction
Tagcloud ?		apocrine ar conclusiontogether crossed epithelium exclusively find gcdfp gland introductionperiostin mammary methodsusing mmtv neu notch null oncogene outgrowth periostin pip postn prolactin proliferate rescued resultsalthough stromal surprisingly transplanted wildtype	bioinformatics cd53 coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Difference) ?		apocrine ar conclusiontogether crossed epithelium exclusively find gcdfp gland introductionperiostin mammary methodsusing mmtv neu notch null oncogene outgrowth periostin pip postn prolactin proliferate rescued resultsalthough stromal surprisingly transplanted wildtype	bioinformatics cd53 coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Intersection) ?