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RAB8A and MAP4K2
Number of citations of the paper that reports this interaction (PMID
8643544
)
19
Data Source:
HPRD
(in vivo)
RAB8A
MAP4K2
Gene Name
RAB8A, member RAS oncogene family
mitogen-activated protein kinase kinase kinase kinase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Nucleolus
Centrosome
Cytosol
Plasma Membrane
Cilium
Synaptic Vesicle
Postsynaptic Density
Trans-Golgi Network Transport Vesicle
Dendrite
Cytoplasmic Vesicle Membrane
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Nonmotile Primary Cilium
Ciliary Basal Body
Neuronal Cell Body
Phagocytic Vesicle
Recycling Endosome Membrane
Extracellular Vesicular Exosome
Primary Cilium
Golgi Membrane
Cytoplasm
Basolateral Plasma Membrane
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Rab GTPase Binding
GDP Binding
Protein Kinase Binding
Myosin V Binding
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Small GTPase Regulator Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Intracellular Protein Transport
Vesicle Docking Involved In Exocytosis
Organelle Organization
Axonogenesis
Protein Secretion
Synaptic Vesicle Exocytosis
Regulation Of Exocytosis
Rab Protein Signal Transduction
Cellular Response To Insulin Stimulus
Cilium Assembly
Regulation Of Long-term Neuronal Synaptic Plasticity
Golgi Vesicle Fusion To Target Membrane
Regulation Of Protein Transport
Membrane Organization
Protein Localization To Plasma Membrane
Protein Phosphorylation
Vesicle Targeting
Immune Response
JNK Cascade
Activation Of JUN Kinase Activity
Intracellular Signal Transduction
Innate Immune Response
Positive Regulation Of JNK Cascade
Pathways
Cargo trafficking to the periciliary membrane
Organelle biogenesis and maintenance
Translocation of GLUT4 to the plasma membrane
VxPx cargo-targeting to cilium
G2/M Transition
Assembly of the primary cilium
Mitotic G2-G2/M phases
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Urate levels (
21768215
)
Protein-Protein Interactions
20 interactors:
BAG6
BIRC6
GDI2
MAP4K2
MDM2
MYO5B
MYO5C
OCRL
ODF2
OPTN
PDE6D
PQBP1
RAB3IP
RABIF
RIMS2
RPH3A
RPH3AL
SYTL1
SYTL4
TFRC
13 interactors:
DEFB1
HNRNPA2B1
MAP2K4
MAP3K11
MCM3AP-AS1
NACAD
POT1
PRDX4
RAB8A
SERPINA4
SNRNP35
TRAF2
XRCC6
Entrez ID
4218
5871
HPRD ID
01296
04408
Ensembl ID
ENSG00000168067
Uniprot IDs
B4DEK7
P61006
Q12851
Q86VU3
PDB IDs
3QBT
3TNF
Enriched GO Terms of Interacting Partners
?
Establishment Of Protein Localization
Protein Localization
Protein Transport
Vesicle-mediated Transport
Cellular Protein Localization
Cellular Localization
Intracellular Protein Transport
Transport
Establishment Of Localization In Cell
Intracellular Transport
Exocytosis
Regulation Of Exocytosis
Regulation Of Catalytic Activity
Golgi To Plasma Membrane Transport
Regulation Of Signaling
Intracellular Signal Transduction
Secretion By Cell
Protein Localization To Organelle
Cellular Response To UV-C
Cellular Response To Vitamin B1
Establishment Of Protein Localization To Membrane
Regulation Of Signal Transduction
Cell Cycle Process
Secretion
Mitotic Cell Cycle Process
Negative Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Transport
Organelle Organization
Post-Golgi Vesicle-mediated Transport
Positive Regulation Of GTPase Activity
Negative Regulation Of Proteolysis
Mitotic Cell Cycle
Protein Localization To Membrane
Negative Regulation Of Protein Processing
Traversing Start Control Point Of Mitotic Cell Cycle
Multivesicular Body Sorting Pathway
Negative Regulation Of Receptor Recycling
Regulation Of Vesicle-mediated Transport
Regulation Of GTPase Activity
Response To Vitamin B1
Response To Ether
Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Signal Transduction By P53 Class Mediator
Cell Cycle
Regulation Of Protein Processing
G2/M Transition Of Mitotic Cell Cycle
Membrane Organization
Positive Regulation Of Rab GTPase Activity
Regulation Of Rab GTPase Activity
Positive Regulation Of JUN Kinase Activity
Regulation Of JUN Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of JNK Cascade
Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Transferase Activity
Positive Regulation Of MAP Kinase Activity
Activation Of JUN Kinase Activity
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Neuron Death
Regulation Of MAP Kinase Activity
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Innate Immune Response
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of DNA Replication
Telomere Maintenance
Positive Regulation Of DNA Strand Elongation
Negative Regulation Of Male Germ Cell Proliferation
Positive Regulation Of Neuron Death
DNA Duplex Unwinding
DNA Geometric Change
Toll-like Receptor 4 Signaling Pathway
JNK Cascade
Positive Regulation Of MAPK Cascade
Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Cellular Hyperosmotic Salinity Response
Regulation Of Male Germ Cell Proliferation
Golgi Vesicle Fusion To Target Membrane
Telomere Formation Via Telomerase
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Kinase Activity
Regulation Of DNA Replication
Cellular Response To Sorbitol
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of MAPK Activity
Activation Of Innate Immune Response
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Cellular Response To X-ray
Tagcloud
?
apical
assemble
cdc42
directs
exchange
exocyst
exocytosis
gef
generate
guanine
hypothesized
interconnection
lumen
machineries
must
novo
organs
par3
polarity
polarization
polarize
polarized
rab11a
rabin8
revealing
traffic
tuba
vesicular
Tagcloud (Difference)
?
apical
assemble
cdc42
directs
exchange
exocyst
exocytosis
gef
generate
guanine
hypothesized
interconnection
lumen
machineries
must
novo
organs
par3
polarity
polarization
polarize
polarized
rab11a
rabin8
revealing
traffic
tuba
vesicular
Tagcloud (Intersection)
?