RAB8A and GDI2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vitro)

		RAB8A	GDI2
Description		RAB8A, member RAS oncogene family	GDP dissociation inhibitor 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosome Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Membrane Trans-Golgi Network Transport Vesicle Dendrite Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding Protein Tyrosine Kinase Binding	RNA Binding GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Exocytosis Vesicle Docking Involved In Exocytosis Autophagy Golgi Organization Axonogenesis Regulation Of Autophagy Protein Transport Cell Projection Organization Endocytic Recycling Cellular Response To Insulin Stimulus Regulation Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Signal Transduction Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Negative Regulation Of Cilium Assembly Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494)	Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Heel bone mineral density x serum urate levels interaction ( 34046847) Osteosarcoma ( 23727862)
Interacting Genes		23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC	12 interacting genes: CEBPA GLRA2 HSPB1 LINC00632 LINC01554 OGT RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A
Entrez ID		4218	2665
HPRD ID		01296	02863
Ensembl ID		ENSG00000167461	ENSG00000057608
Uniprot IDs		P61006	P50395 Q6IAT1
PDB IDs		3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6WHE 6YX5 6ZSI 6ZSJ 7BWT 7LWB 9IKQ
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Establishment Of Protein Localization Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Localization Cytoplasmic Vesicle Golgi To Plasma Membrane Transport Secretion By Cell Endosome Trans-Golgi Network Recycling Endosome Membrane Secretion Polyubiquitin Modification-dependent Protein Binding Spontaneous Neurotransmitter Secretion Intracellular Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Intracellular Signal Transduction Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Positive Regulation Of Protein Localization Golgi Vesicle Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytosol Membrane Interleukin-2-mediated Signaling Pathway Spindle Pole Organelle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Neurexin Family Protein Binding Signal Transduction Organelle Localization By Membrane Tethering Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Positive Regulation Of Protein Export From Nucleus Membrane Docking Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization To Membrane Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Cilium Assembly Regulation Of Cell Projection Assembly K63-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Vesicle Localization	GDP Binding G Protein Activity GTPase Activity GTP Binding Phagocytic Vesicle Regulation Of Long-term Neuronal Synaptic Plasticity Protein Transport Receptor Localization To Synapse Protein Localization To Synapse Intracellular Protein Localization Regulation Of Neuronal Synaptic Plasticity Amyloid-beta Clearance By Transcytosis Establishment Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Plasma Membrane To Endosome Transport Establishment Of Protein Localization To Postsynaptic Membrane Phagocytic Vesicle Membrane Neurotransmitter Receptor Transport To Plasma Membrane HMG Box Domain Binding Protein Localization To Cell Junction Endosomal Transport Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Recycling Endosome Membrane Melanosome Myosin V Binding Trans-Golgi Network Membrane Rab Protein Signal Transduction Transcytosis Vesicle-mediated Transport Intracellular Transport Recycling Endosome Endosome Amyloid-beta Clearance Membrane Fusion Protein Localization To Postsynaptic Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Membrane Protein Localization To Postsynapse Extracellular Exosome RNA Polymerase II-specific DNA-binding Transcription Factor Binding Modulation Of Chemical Synaptic Transmission Vesicle Docking Involved In Exocytosis Regulation Of Synaptic Plasticity Cellular Localization Establishment Of Localization In Cell Macrophage Differentiation
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