RAB8A and MYO5C

Number of citations of the paper that reports this interaction (PubMedID 17507647)
46

Data Source:
BioGRID (two hybrid)

		RAB8A	MYO5C
Description		RAB8A, member RAS oncogene family	myosin VC
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosome Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Membrane Trans-Golgi Network Transport Vesicle Dendrite Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse	Cytoplasm Actin Cytoskeleton Membrane Myosin Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding Protein Tyrosine Kinase Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Exocytosis Vesicle Docking Involved In Exocytosis Autophagy Golgi Organization Axonogenesis Regulation Of Autophagy Protein Transport Cell Projection Organization Endocytic Recycling Cellular Response To Insulin Stimulus Regulation Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Endocytosis Actin Filament Organization Vesicle Transport Along Actin Filament
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494)	Glucose homeostasis traits ( 25524916) Hip circumference adjusted for BMI ( 28552196) Systemic lupus erythematosus ( 32771030) Type 2 diabetes ( 32499647)
Interacting Genes		23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC	4 interacting genes: CRYAA IKBKG POT1 RAB8A
Entrez ID		4218	55930
HPRD ID		01296	11380
Ensembl ID		ENSG00000167461	ENSG00000128833
Uniprot IDs		P61006	Q9NQX4
PDB IDs		3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6WHE 6YX5 6ZSI 6ZSJ 7BWT 7LWB 9IKQ	4L8T 4ZG4 5HMP
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Establishment Of Protein Localization Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Localization Cytoplasmic Vesicle Golgi To Plasma Membrane Transport Secretion By Cell Endosome Trans-Golgi Network Recycling Endosome Membrane Secretion Polyubiquitin Modification-dependent Protein Binding Spontaneous Neurotransmitter Secretion Intracellular Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Intracellular Signal Transduction Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Positive Regulation Of Protein Localization Golgi Vesicle Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytosol Membrane Interleukin-2-mediated Signaling Pathway Spindle Pole Organelle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Neurexin Family Protein Binding Signal Transduction Organelle Localization By Membrane Tethering Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Positive Regulation Of Protein Export From Nucleus Membrane Docking Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization To Membrane Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Cilium Assembly Regulation Of Cell Projection Assembly K63-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Vesicle Localization	Embryonic Eye Morphogenesis Eye Morphogenesis Sensory Organ Morphogenesis Camera-type Eye Development Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Embryonic Organ Morphogenesis Eye Development Sensory Organ Development Cellular Response To Peptide Hormone Stimulus Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Response To Food Sequestering Of TGFbeta In Extracellular Matrix Positive Regulation Of Appetite Activation Of Protein Kinase A Activity Golgi Vesicle Fusion To Target Membrane Linear Polyubiquitin Binding Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Osteoclast Development Single-stranded Telomeric DNA Binding Cellular Component Assembly Shelterin Complex Lens Fiber Cell Morphogenesis Post-embryonic Eye Morphogenesis IkappaB Kinase Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Tubulin Complex Assembly Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Response To Peptide Hormone Regulation Of Osteoclast Development Cellular Response To Insulin-like Growth Factor Stimulus Extracellular Matrix Constituent Conferring Elasticity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Transferrin Receptor Binding Nuclear Telomere Cap Complex Telomeric Loop Disassembly Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding G-rich Strand Telomeric DNA Binding
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