RAB8A and BIRC6

Number of citations of the paper that reports this interaction (PMID 18329369)
45

Data Source:
HPRD (in vivo)

		RAB8A	BIRC6
Gene Name		RAB8A, member RAS oncogene family	baculoviral IAP repeat containing 6
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Centrosome Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Nonmotile Primary Cilium Ciliary Basal Body Neuronal Cell Body Phagocytic Vesicle Recycling Endosome Membrane Extracellular Vesicular Exosome Primary Cilium	Spindle Pole Endosome Trans-Golgi Network Microtubule Organizing Center Membrane Midbody
	Molecular Function	GTPase Activity Protein Binding GTP Binding Rab GTPase Binding GDP Binding Protein Kinase Binding Myosin V Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Ligase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Organelle Organization Axonogenesis Protein Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Cilium Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Membrane Organization Protein Localization To Plasma Membrane	Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Spongiotrophoblast Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium G2/M Transition Assembly of the primary cilium Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BAG6 BIRC6 GDI2 MAP4K2 MDM2 MYO5B MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC	19 interactors: BIRC5 CASP3 CASP7 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 HTRA2 MAP2K1 PLK1 RAB8A RNF41 UBC UBE2D1 USP8 VAV2
Entrez ID		4218	57448
HPRD ID		01296	05731
Ensembl ID			ENSG00000115760
Uniprot IDs		B4DEK7 P61006	Q9NR09
PDB IDs		3QBT 3TNF	3CEG
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Localization Protein Transport Vesicle-mediated Transport Cellular Protein Localization Cellular Localization Intracellular Protein Transport Transport Establishment Of Localization In Cell Intracellular Transport Exocytosis Regulation Of Exocytosis Regulation Of Catalytic Activity Golgi To Plasma Membrane Transport Regulation Of Signaling Intracellular Signal Transduction Secretion By Cell Protein Localization To Organelle Cellular Response To UV-C Cellular Response To Vitamin B1 Establishment Of Protein Localization To Membrane Regulation Of Signal Transduction Cell Cycle Process Secretion Mitotic Cell Cycle Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Transport Organelle Organization Post-Golgi Vesicle-mediated Transport Positive Regulation Of GTPase Activity Negative Regulation Of Proteolysis Mitotic Cell Cycle Protein Localization To Membrane Negative Regulation Of Protein Processing Traversing Start Control Point Of Mitotic Cell Cycle Multivesicular Body Sorting Pathway Negative Regulation Of Receptor Recycling Regulation Of Vesicle-mediated Transport Regulation Of GTPase Activity Response To Vitamin B1 Response To Ether Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Signal Transduction By P53 Class Mediator Cell Cycle Regulation Of Protein Processing G2/M Transition Of Mitotic Cell Cycle Membrane Organization Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity	Regulation Of Proteolysis Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cell Death Apoptotic Signaling Pathway Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Mitotic Cell Cycle Process Positive Regulation Of Peptidase Activity Negative Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Mitotic Cell Cycle Proteolysis Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Cellular Macromolecule Catabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Protein Catabolic Process Zymogen Activation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		apical assemble cdc42 directs exchange exocyst exocytosis gef generate guanine hypothesized interconnection lumen machineries must novo organs par3 polarity polarization polarize polarized rab11a rabin8 revealing traffic tuba vesicular	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Difference) ?		apical assemble cdc42 directs exchange exocyst exocytosis gef generate guanine hypothesized interconnection lumen machineries must novo organs par3 polarity polarization polarize polarized rab11a rabin8 revealing traffic tuba vesicular	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Intersection) ?