CCDC28B and PRKAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC28B	PRKAB2
Description		coiled-coil domain containing 28B	protein kinase AMP-activated non-catalytic subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Cell Projection Organization Cilium Assembly	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Cellular Response To Nutrient Levels Positive Regulation Of Cold-induced Thermogenesis
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS
Interacting Genes		10 interacting genes: APP ARMC7 ATRIP ENKD1 GRB2 PRKAB2 SCNM1 TRIM55 TRIM63 UBL5	172 interacting genes: ABHD11 ACTMAP ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BLZF1 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFAP68 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GPRASP3 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRABD4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PPP1R3B PPP1R3C PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		79140	5565
HPRD ID		14422	04117
Ensembl ID		ENSG00000160050	ENSG00000131791
Uniprot IDs		A0A7P0TB33 Q9BUN5	O43741 X5D2Z8
PDB IDs			2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E 7JHG 7JHH 7JIJ 7M74
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Amylin Binding Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Guanyl-nucleotide Exchange Factor Adaptor Activity Acetylcholine Receptor Activator Activity Response To Interleukin-1 Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Grb2-EGFR Complex RNA Splicing Microtubule ATR-ATRIP Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization MRNA Processing Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Growth Factor Receptor Binding Main Axon Response To Other Organism Regulation Of Generation Of Precursor Metabolites And Energy	Keratin Filament Intermediate Filament Protein Binding Identical Protein Binding AMP-activated Protein Kinase Activity Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway P53 Binding Glycogen Binding Nucleotide-activated Protein Kinase Complex
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