ARL6IP5 and ARL6

Number of citations: 0 (PubMedID 10508919)
Data Source: HPRD (two hybrid)

		ARL6IP5	ARL6
Name		ARF like GTPase 6 interacting protein 5	ARF like GTPase 6
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Presynaptic Cytosol	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Membrane Coat Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Negative Regulation Of L-glutamate Import Across Plasma Membrane Glutathione Metabolic Process Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential Protein Transport L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Transport Protein Localization To Plasma Membrane L-glutamate Import Across Plasma Membrane	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Protein Transport Wnt Signaling Pathway Vesicle-mediated Transport Cell Projection Organization Melanosome Transport Fat Cell Differentiation Protein Polymerization Cilium Assembly Protein Localization To Cilium Protein Localization To Non-motile Cilium Protein Transport From Ciliary Membrane To Plasma Membrane
Pathways		Glutamate Neurotransmitter Release Cycle	BBSome-mediated cargo-targeting to cilium
Diseases		None	Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)
GWAS		Urate levels ( 31578528 )	Male infertility ( 19478329 )
Novel Interactors		None recorded	6 novel interactors: ARL13B CEBPD CRYBG3 GLS PROS1 SYNRG
Interacting Genes		10 interacting genes: ARL6 CCR2 CCR5 CLN8 KRAS MYCBP2 NOTCH1 PRAF2 SLC1A1 VKORC1	6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B
Entrez ID		10550	84100
HPRD ID		09303	10588
Ensembl ID		ENSG00000144746	ENSG00000113966
Uniprot IDs		O75915	Q9H0F7
PDB IDs		Not available	2H57
GO Terms Enriched among Interactors		Nervous System Process L-glutamate Transmembrane Transport L-glutamate Import Homeostasis Of Number Of Cells Within A Tissue Cytokine-mediated Signaling Pathway Acidic Amino Acid Transport System Process Anatomical Structure Homeostasis Tissue Homeostasis L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Dicarboxylic Acid Transport Amino Acid Transmembrane Transport L-glutamate Import Across Plasma Membrane Associative Learning Neuron Apoptotic Process Dendritic Cell Chemotaxis Amino Acid Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Chemokine Receptor Activity Cell Death Apoptotic Process Dendritic Cell Migration Negative Regulation Of Programmed Cell Death C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Apoptotic Process Programmed Cell Death Learning Membrane Negative Regulation Of Neuron Apoptotic Process Retina Layer Formation Cardiac Muscle Cell Proliferation Multicellular Organismal-level Homeostasis Homeostasis Of Number Of Cells Identical Protein Binding Amino Acid Import Across Plasma Membrane Negative Regulation Of Exocytosis Regulation Of Chemotaxis Cell Differentiation In Spinal Cord Regulation Of Glial Cell Proliferation Presynapse Muscle Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Epithelial Cell Differentiation Cellular Defense Response Carboxylic Acid Transport Organic Acid Transport	Regulation Of L-glutamate Import Across Plasma Membrane Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Cellular Localization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Organization Negative Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Amine Transport