ARL6IP5 and SLC1A1

Number of citations: 0 (PubMedID 11242046)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		ARL6IP5	SLC1A1
Name		ARF like GTPase 6 interacting protein 5	solute carrier family 1 member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Presynaptic Cytosol	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Vesicle Asymmetric Synapse Neuron Projection Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Synapse Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Schaffer Collateral - CA1 Synapse Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Protein Binding	Monoatomic Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of L-glutamate Import Across Plasma Membrane Glutathione Metabolic Process Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential Protein Transport L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Transport Protein Localization To Plasma Membrane L-glutamate Import Across Plasma Membrane	Behavioral Fear Response Response To Amphetamine Regulation Of Heart Rate Glutathione Metabolic Process Glutathione Biosynthetic Process Superoxide Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Grooming Behavior Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Cellular Response To Oxidative Stress Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization Neuron Apoptotic Process L-glutamate Import Righting Reflex Retina Development In Camera-type Eye Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transmembrane Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Intracellular Glutamate Homeostasis Motor Neuron Apoptotic Process Import Into Cell L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Cellular Response To Bisphenol A Conditioned Place Preference
Pathways		Glutamate Neurotransmitter Release Cycle	Glutamate Neurotransmitter Release Cycle Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC-mediated transport of amino acids
Drugs		None	Aspartic acid Glutamic acid
Diseases		None	Dicarboxylic aminoaciduria
GWAS		Urate levels ( 31578528 )	Coronary artery calcification ( 23870195 ) Metabolite levels ( 23823483 ) Pancreatic cancer ( 22158540 ) Response to antipsychotic treatment in schizophrenia ( 29503163 ) Response to risperidone in schizophrenia ( 29503163 ) Squamous cell lung carcinoma ( 28604730 )
Interacting Genes		10 interacting genes: ARL6 CCR2 CCR5 CLN8 KRAS MYCBP2 NOTCH1 PRAF2 SLC1A1 VKORC1	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		10550	6505
HPRD ID		09303	00597
Ensembl ID		ENSG00000144746	ENSG00000106688
Uniprot IDs		O75915	P43005
PDB IDs		Not available	6S3Q 6X2L 6X2Z 6X3E 6X3F 7NSG 8CTC 8CTD 8CUA 8CUD 8CUI 8CUJ 8CV2 8CV3 9D66 9D67 9D68 9D69 9D6A
GO Terms Enriched among Interactors		Nervous System Process L-glutamate Transmembrane Transport L-glutamate Import Homeostasis Of Number Of Cells Within A Tissue Cytokine-mediated Signaling Pathway Acidic Amino Acid Transport System Process Anatomical Structure Homeostasis Tissue Homeostasis L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Dicarboxylic Acid Transport Amino Acid Transmembrane Transport L-glutamate Import Across Plasma Membrane Associative Learning Neuron Apoptotic Process Dendritic Cell Chemotaxis Amino Acid Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Chemokine Receptor Activity Cell Death Apoptotic Process Dendritic Cell Migration Negative Regulation Of Programmed Cell Death C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Apoptotic Process Programmed Cell Death Learning Membrane Negative Regulation Of Neuron Apoptotic Process Retina Layer Formation Cardiac Muscle Cell Proliferation Multicellular Organismal-level Homeostasis Homeostasis Of Number Of Cells Identical Protein Binding Amino Acid Import Across Plasma Membrane Negative Regulation Of Exocytosis Regulation Of Chemotaxis Cell Differentiation In Spinal Cord Regulation Of Glial Cell Proliferation Presynapse Muscle Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Epithelial Cell Differentiation Cellular Defense Response Carboxylic Acid Transport Organic Acid Transport	None