ARL6IP5 and SLC1A1

Number of citations of the paper that reports this interaction (PMID 11242046)
17

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARL6IP5	SLC1A1
Gene Name		ADP-ribosylation factor-like 6 interacting protein 5	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein C-terminus Binding	L-glutamate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Sodium:dicarboxylate Symporter Activity Cysteine Transmembrane Transporter Activity
	Biological Process	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transport	Ion Transport Synaptic Transmission Cysteine Transport Protein Homooligomerization L-glutamate Import Transmembrane Transport D-aspartate Import L-glutamate Transmembrane Transport
Pathways			Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			L-Aspartic Acid L-Glutamic Acid
Diseases
GWAS			Pancreatic cancer ( 22158540)
Protein-Protein Interactions		7 interactors: ARL6 CCR5 CLN8 PRAF2 RNF185 SLC1A1 VKORC1	6 interactors: APP ARL6IP5 EWSR1 LDLRAD1 PRKCA RNF5
Entrez ID		10550	6505
HPRD ID		09303	00597
Ensembl ID		ENSG00000144746	ENSG00000106688
Uniprot IDs		O75915	P43005
PDB IDs
Enriched GO Terms of Interacting Partners?		L-glutamate Transport Dicarboxylic Acid Transport L-glutamate Import Amino Acid Import Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Cysteine Transport Intermembrane Transport L-glutamate Uptake Involved In Synaptic Transmission Anion Transport D-aspartate Import Ion Transport Retina Development In Camera-type Eye Visual Perception Sensory Perception Of Light Stimulus Age-dependent Response To Oxidative Stress Vitamin K Metabolic Process Somatic Motor Neuron Differentiation Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Aspartate Transport Sarcoplasmic Reticulum Calcium Ion Transport Neurotransmitter Uptake Protein Localization To Cilium Peptidyl-glutamic Acid Carboxylation Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Camera-type Eye Development Neuromuscular Process Controlling Posture Eye Development L-glutamate Transmembrane Transport Transport Response To Cholesterol Dendritic Cell Migration Retina Layer Formation Photoreceptor Cell Maintenance Melanosome Transport Release Of Sequestered Calcium Ion Into Cytosol Pigment Granule Transport Establishment Of Melanosome Localization Quinone Metabolic Process Drug Metabolic Process Regulation Of Sequestering Of Calcium Ion Sensory Organ Development Social Behavior Intermediate Filament Cytoskeleton Organization Melanosome Localization Entry Into Host Cell Intermediate Filament-based Process	Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Collateral Sprouting In Absence Of Injury ER-associated Misfolded Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Regulation Of Phosphorylation Calcium Ion Homeostasis Neuron Remodeling Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Response To Stress Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of Glucose Import Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Desmosome Organization Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Membrane Potential Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Misfolded Or Incompletely Synthesized Protein Catabolic Process
Tagcloud ?		abundantly acceptor adp belongs calmodulin ccaat chop delta2 enhances exocytic expresses histomorphometric hormones insufficiency knock knocked mineral osteoblast osteoblastic osteoblasts osteoclast osteoclastogenesis precursors prenylated rab rankl resorption ribosylation trabecular	agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged
Tagcloud (Difference) ?		abundantly acceptor adp belongs calmodulin ccaat chop delta2 enhances exocytic expresses histomorphometric hormones insufficiency knock knocked mineral osteoblast osteoblastic osteoblasts osteoclast osteoclastogenesis precursors prenylated rab rankl resorption ribosylation trabecular	agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged
Tagcloud (Intersection) ?