ARL6IP5 and CLN8

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		ARL6IP5	CLN8
Gene Name		ADP-ribosylation factor-like 6 interacting protein 5	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function Protein C-terminus Binding
	Biological Process	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential L-glutamate Transport Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transport	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Gaucher disease severity ( 22388998)
Protein-Protein Interactions		7 interactors: ARL6 CCR5 CLN8 PRAF2 RNF185 SLC1A1 VKORC1	29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP
Entrez ID		10550	2055
HPRD ID		09303	06383
Ensembl ID		ENSG00000144746	ENSG00000182372
Uniprot IDs		O75915	Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		L-glutamate Transport Dicarboxylic Acid Transport L-glutamate Import Amino Acid Import Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Cysteine Transport Intermembrane Transport L-glutamate Uptake Involved In Synaptic Transmission Anion Transport D-aspartate Import Ion Transport Retina Development In Camera-type Eye Visual Perception Sensory Perception Of Light Stimulus Age-dependent Response To Oxidative Stress Vitamin K Metabolic Process Somatic Motor Neuron Differentiation Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Aspartate Transport Sarcoplasmic Reticulum Calcium Ion Transport Neurotransmitter Uptake Protein Localization To Cilium Peptidyl-glutamic Acid Carboxylation Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Camera-type Eye Development Neuromuscular Process Controlling Posture Eye Development L-glutamate Transmembrane Transport Transport Response To Cholesterol Dendritic Cell Migration Retina Layer Formation Photoreceptor Cell Maintenance Melanosome Transport Release Of Sequestered Calcium Ion Into Cytosol Pigment Granule Transport Establishment Of Melanosome Localization Quinone Metabolic Process Drug Metabolic Process Regulation Of Sequestering Of Calcium Ion Sensory Organ Development Social Behavior Intermediate Filament Cytoskeleton Organization Melanosome Localization Entry Into Host Cell Intermediate Filament-based Process	Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?		abundantly acceptor adp belongs calmodulin ccaat chop delta2 enhances exocytic expresses histomorphometric hormones insufficiency knock knocked mineral osteoblast osteoblastic osteoblasts osteoclast osteoclastogenesis precursors prenylated rab rankl resorption ribosylation trabecular	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?		abundantly acceptor adp belongs calmodulin ccaat chop delta2 enhances exocytic expresses histomorphometric hormones insufficiency knock knocked mineral osteoblast osteoblastic osteoblasts osteoclast osteoclastogenesis precursors prenylated rab rankl resorption ribosylation trabecular	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?