ARL6IP5 and MYCBP2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		ARL6IP5	MYCBP2
Description		ARF like GTPase 6 interacting protein 5	MYC binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Membrane Presynaptic Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of L-glutamate Import Across Plasma Membrane Glutathione Metabolic Process Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Potential Protein Transport L-glutamate Transmembrane Transport Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Transport Protein Localization To Plasma Membrane L-glutamate Import Across Plasma Membrane	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance
Pathways		Glutamate Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		Urate levels ( 31578528)	Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		10 interacting genes: ARL6 CCR2 CCR5 CLN8 KRAS MYCBP2 NOTCH1 PRAF2 SLC1A1 VKORC1	50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ
Entrez ID		10550	23077
HPRD ID		09303	10104
Ensembl ID		ENSG00000144746	ENSG00000005810
Uniprot IDs		O75915	O75592
PDB IDs			5O6C 6T7F
Enriched GO Terms of Interacting Partners?		Nervous System Process L-glutamate Transmembrane Transport L-glutamate Import Homeostasis Of Number Of Cells Within A Tissue Cytokine-mediated Signaling Pathway Acidic Amino Acid Transport System Process Anatomical Structure Homeostasis Tissue Homeostasis L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Dicarboxylic Acid Transport Amino Acid Transmembrane Transport L-glutamate Import Across Plasma Membrane Associative Learning Neuron Apoptotic Process Dendritic Cell Chemotaxis Amino Acid Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Chemokine Receptor Activity Cell Death Apoptotic Process Dendritic Cell Migration Negative Regulation Of Programmed Cell Death C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Apoptotic Process Programmed Cell Death Learning Membrane Negative Regulation Of Neuron Apoptotic Process Retina Layer Formation Cardiac Muscle Cell Proliferation Multicellular Organismal-level Homeostasis Homeostasis Of Number Of Cells Identical Protein Binding Amino Acid Import Across Plasma Membrane Negative Regulation Of Exocytosis Regulation Of Chemotaxis Cell Differentiation In Spinal Cord Regulation Of Glial Cell Proliferation Presynapse Muscle Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Epithelial Cell Differentiation Cellular Defense Response Carboxylic Acid Transport Organic Acid Transport	Cytoplasm Intracellular Signal Transduction
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