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RNF115 and CST3
Number of citations of the paper that reports this interaction (PMID
22315970
)
6
Data Source:
BioGRID
(two hybrid)
RNF115
CST3
Gene Name
ring finger protein 115
cystatin C
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Extracellular Region
Extracellular Space
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Activity
Beta-amyloid Binding
Protease Binding
Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Biological Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Defense Response
Negative Regulation Of Peptidase Activity
Negative Regulation Of Collagen Catabolic Process
Negative Regulation Of Extracellular Matrix Disassembly
Negative Regulation Of Endopeptidase Activity
Regulation Of Tissue Remodeling
Extracellular Fibril Organization
Negative Regulation Of Proteolysis
Negative Regulation Of Elastin Catabolic Process
Negative Regulation Of Blood Vessel Remodeling
Pathways
Amyloids
Drugs
Diseases
GWAS
Chronic kidney disease (
20383146
)
Cystatin C (
17903292
)
Protein-Protein Interactions
27 interactors:
AKT1
APP
ATN1
CDK10
CST3
DAZAP2
DOCK4
EGFR
FOLR3
HRAS
IGHA1
MDM4
MFAP4
RAB7A
RAD23A
RPL18A
SSSCA1
TTR
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E3
UBE2I
UBE2N
UBE2W
9 interactors:
ATXN1
C4A
CSTB
CTSB
CTSD
CTSL
CTSS
PDZD2
RNF115
Entrez ID
27246
1471
HPRD ID
18328
05056
Ensembl ID
ENSG00000101439
Uniprot IDs
Q9Y4L5
P01034
PDB IDs
1G96
1R4C
1TIJ
3GAX
3NX0
3PS8
3QRD
3S67
3SVA
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Proteolysis Involved In Cellular Protein Catabolic Process
Response To Abiotic Stimulus
Cellular Response To Oxygen Levels
Regulation Of Protein Catabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Defense Response
Catabolic Process
Cellular Protein Modification Process
Response To Light Stimulus
Innate Immune Response
Positive Regulation Of Transferase Activity
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Immune Response
Protein Metabolic Process
Mitotic Cell Cycle Process
Toll-like Receptor Signaling Pathway
Protein K63-linked Ubiquitination
Response To Radiation
Cell Cycle Process
Regulation Of Cell Cycle Process
Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Protein Monoubiquitination
Regulation Of Metabolic Process
Response To Hypoxia
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To UV-A
Activation Of Innate Immune Response
Response To Stress
Cellular Response To Thyroid Hormone Stimulus
Collagen Catabolic Process
Collagen Metabolic Process
Multicellular Organismal Macromolecule Metabolic Process
Response To Thyroid Hormone
Multicellular Organismal Metabolic Process
Extracellular Matrix Disassembly
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Extracellular Matrix Organization
Extracellular Structure Organization
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Positive Regulation Of Innate Immune Response
Protein Catabolic Process
Positive Regulation Of Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Regulation Of Innate Immune Response
Proteolysis
Adaptive Immune Response
Antigen Processing And Presentation
Innate Immune Response
Cellular Macromolecule Catabolic Process
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Catabolic Process
Immune System Process
Immune Response-regulating Signaling Pathway
Basement Membrane Disassembly
Macrophage Apoptotic Process
Adult Locomotory Behavior
Immune Response
Regulation Of Immune System Process
Defense Response
Cellular Response To Hormone Stimulus
Adult Behavior
Myeloid Cell Apoptotic Process
Positive Regulation Of Apoptotic Cell Clearance
Inflammatory Cell Apoptotic Process
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Locomotory Behavior
Regulation Of Apoptotic Cell Clearance
Negative Regulation Of Endopeptidase Activity
Response To Hormone
Negative Regulation Of Peptidase Activity
Tagcloud
?
airflow
analysing
antiprotease
bronchial
brushings
categorical
causal
causality
cd22
copd
curation
cystatin
dataset
datasets
eqtl
fev
fvc
genomics
integrative
manual
modelling
oxidant
relations
silico
snps
trait
triplets
upregulating
xenobiotic
Tagcloud (Difference)
?
airflow
analysing
antiprotease
bronchial
brushings
categorical
causal
causality
cd22
copd
curation
cystatin
dataset
datasets
eqtl
fev
fvc
genomics
integrative
manual
modelling
oxidant
relations
silico
snps
trait
triplets
upregulating
xenobiotic
Tagcloud (Intersection)
?