RNF115 and MFAP4

Number of citations of the paper that reports this interaction (PMID 22315970)
6

Data Source:
BioGRID (two hybrid)

		RNF115	MFAP4
Gene Name		ring finger protein 115	microfibrillar-associated protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Microfibril Extracellular Region Extracellular Matrix Extracellular Vesicular Exosome Elastic Fiber
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Extracellular Matrix Organization Extracellular Fibril Organization Elastic Fiber Assembly Cellular Response To UV-B
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 RAB7A RAD23A RPL18A SSSCA1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W	2 interactors: RNF115 SFTPD
Entrez ID		27246	4239
HPRD ID		18328	02789
Ensembl ID			ENSG00000166482
Uniprot IDs		Q9Y4L5	P55083
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Oxygen Levels Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-regulating Signaling Pathway Defense Response Catabolic Process Cellular Protein Modification Process Response To Light Stimulus Innate Immune Response Positive Regulation Of Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Immune Response Protein Metabolic Process Mitotic Cell Cycle Process Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination Response To Radiation Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Regulation Of Metabolic Process Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Activation Of Innate Immune Response Response To Stress	Negative Regulation Of Interleukin-2 Biosynthetic Process Surfactant Homeostasis Chemical Homeostasis Within A Tissue Macrophage Chemotaxis Negative Regulation Of Interleukin-2 Production Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Interleukin-2 Biosynthetic Process Protein K63-linked Ubiquitination Negative Regulation Of Cytokine Biosynthetic Process Protein K48-linked Ubiquitination Protein Autoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Phagocytosis Lung Alveolus Development Respiratory Gaseous Exchange Negative Regulation Of T Cell Proliferation Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Leukocyte Proliferation Regulation Of ERBB Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Chemotaxis Positive Regulation Of Endocytosis Negative Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cytokine Biosynthetic Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of T Cell Proliferation
Tagcloud ?			acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 morphants morpholino mpx myelopoiesis ncor1 ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Difference) ?			acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 morphants morpholino mpx myelopoiesis ncor1 ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Intersection) ?