RNF115 and DOCK4

Number of citations of the paper that reports this interaction (PMID 22315970)
6

Data Source:
BioGRID (two hybrid)

		RNF115	DOCK4
Gene Name		ring finger protein 115	dedicator of cytokinesis 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol Endomembrane System Membrane Stereocilium Stereocilium Bundle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Rac GTPase Activator Activity Receptor Tyrosine Kinase Binding Rac GTPase Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Small GTPase Mediated Signal Transduction Positive Regulation Of Rac GTPase Activity Cell Chemotaxis
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			C-reactive protein and white blood cell count ( 22788528) Response to fenofibrate ( 22890011)
Protein-Protein Interactions		27 interactors: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 RAB7A RAD23A RPL18A SSSCA1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W	3 interactors: FASLG GRB2 RNF115
Entrez ID		27246	9732
HPRD ID		18328	07407
Ensembl ID			ENSG00000128512
Uniprot IDs		Q9Y4L5	Q8N1I0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Oxygen Levels Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-regulating Signaling Pathway Defense Response Catabolic Process Cellular Protein Modification Process Response To Light Stimulus Innate Immune Response Positive Regulation Of Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Immune Response Protein Metabolic Process Mitotic Cell Cycle Process Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination Response To Radiation Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Regulation Of Metabolic Process Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Activation Of Innate Immune Response Response To Stress	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Endosomal Lumen Acidification Retinal Cell Programmed Cell Death Necroptotic Signaling Pathway Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Signal Transduction Response To Growth Factor T Cell Apoptotic Process Regulation Of Signaling Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction PH Reduction Labyrinthine Layer Morphogenesis Positive Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Embryonic Placenta Morphogenesis Necroptotic Process Endosome Organization Protein K63-linked Ubiquitination Regulation Of Endothelial Cell Apoptotic Process Cell-cell Signaling Protein K48-linked Ubiquitination Developmental Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Receptor Internalization Protein Autoubiquitination Regulation Of Intracellular PH Programmed Necrotic Cell Death Anion Homeostasis Regulation Of Cellular PH Necrotic Cell Death Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Labyrinthine Layer Development Cellular Response To Ionizing Radiation Positive Regulation Of Neuron Apoptotic Process
Tagcloud ?			7q 7q22 advance advancement associate biology chromosome cloned commonly cytogenetic del deleted exhibiting ezh2 fish located malignancies mll5 monosomy monosomy7 myeloid samd9 samd9l segments speculating summaries suppressor susceptibility technologies
Tagcloud (Difference) ?			7q 7q22 advance advancement associate biology chromosome cloned commonly cytogenetic del deleted exhibiting ezh2 fish located malignancies mll5 monosomy monosomy7 myeloid samd9 samd9l segments speculating summaries suppressor susceptibility technologies
Tagcloud (Intersection) ?