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RNF115 and HRAS
Number of citations of the paper that reports this interaction (PMID
22315970
)
6
Data Source:
BioGRID
(two hybrid)
RNF115
HRAS
Gene Name
ring finger protein 115
Harvey rat sarcoma viral oncogene homolog
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Golgi Membrane
Nucleus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Activity
Protein Binding
GTP Binding
Protein C-terminus Binding
Biological Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
MAPK Cascade
Activation Of MAPKK Activity
Positive Regulation Of Protein Phosphorylation
Endocytosis
Chemotaxis
Cell Cycle Arrest
Mitotic Cell Cycle Checkpoint
Signal Transduction
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Synaptic Transmission
Axon Guidance
Blood Coagulation
Cell Proliferation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Visual Learning
Fibroblast Growth Factor Receptor Signaling Pathway
Organ Morphogenesis
Negative Regulation Of Gene Expression
Actin Cytoskeleton Organization
Positive Regulation Of Cell Migration
Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Rho GTPase Activity
Positive Regulation Of Rac Protein Signal Transduction
Social Behavior
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Negative Regulation Of Cell Differentiation
Positive Regulation Of DNA Replication
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Epithelial Cell Proliferation
Leukocyte Migration
Striated Muscle Cell Differentiation
Protein Heterooligomerization
Epithelial Tube Branching Involved In Lung Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Wound Healing
Cellular Senescence
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Ruffle Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of MiRNA Metabolic Process
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Signaling by FGFR in disease
SHC-mediated cascade
MEK activation
FCERI mediated MAPK activation
CREB phosphorylation through the activation of Ras
Signaling by EGFRvIII in Cancer
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Interleukin receptor SHC signaling
Gastrin-CREB signalling pathway via PKC and MAPK
p38MAPK events
EPH-Ephrin signaling
SOS-mediated signalling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Signaling by VEGF
Signalling to RAS
Downstream signal transduction
Signaling by FGFR mutants
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Frs2-mediated activation
Transmission across Chemical Synapses
Ras activation uopn Ca2+ infux through NMDA receptor
Adaptive Immune System
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
Axon guidance
IRS-mediated signalling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
EPHB-mediated forward signaling
IRS-related events triggered by IGF1R
EGFR Transactivation by Gastrin
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
Activation of NMDA receptor upon glutamate binding and postsynaptic events
RAF phosphorylates MEK
Downstream signaling of activated FGFR
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Post NMDA receptor activation events
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
SOS-mediated signalling
SHC-mediated signalling
IRS-related events
Cytokine Signaling in Immune system
Signaling by Ligand-Responsive EGFR Variants in Cancer
SHC-related events
NGF signalling via TRKA from the plasma membrane
Tie2 Signaling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell surface interactions at the vascular wall
Signaling by FGFR
ARMS-mediated activation
SHC1 events in EGFR signaling
RAF activation
IRS-mediated signalling
FRS2-mediated cascade
Activation of RAS in B cells
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Interleukin receptor SHC signaling
Constitutive Signaling by EGFRvIII
Drugs
Hexane-1,6-Diol
Trifluoroethanol
Guanosine-5\'-Triphosphate
Guanosine-5\'-Diphosphate
N,N\'-DIMETHYL-N-(ACETYL)-N\'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
AKT1
APP
ATN1
CDK10
CST3
DAZAP2
DOCK4
EGFR
FOLR3
HRAS
IGHA1
MDM4
MFAP4
RAB7A
RAD23A
RPL18A
SSSCA1
TTR
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E3
UBE2I
UBE2N
UBE2W
78 interactors:
AGTR1
ARAF
ARHGEF1
BCL2
BRAF
BRAP
CAV1
CDC25A
CDC25C
DEAF1
DGKZ
FNTA
FNTB
FYN
GPSM2
GRB2
GRIN1
GRIN2D
ICMT
IKZF3
IL3
INSR
IRAK1
IRAK2
ITSN1
KRT18
LGALS1
MAP2K1
MAPK8
MLLT4
NF1
PDE6D
PDGFB
PIK3CA
PIK3CD
PIK3CG
PIK3R1
PLCE1
PRKCI
PRKCZ
RABAC1
RABGEF1
RAF1
RALA
RALGDS
RAP1B
RAP1GDS1
RAPGEF1
RARRES3
RASA1
RASGRF1
RASGRP1
RASGRP4
RASIP1
RASSF1
RASSF2
RASSF5
RGL1
RGL2
RGL4
RGS12
RHOD
RIN1
RIT2
RNF115
SHOC2
SNRPE
SNX17
SOS1
SOS2
SRC
TIAM1
TLR2
TLR9
TP73
TTC1
VAV1
ZBTB12
Entrez ID
27246
3265
HPRD ID
18328
01813
Ensembl ID
ENSG00000174775
Uniprot IDs
Q9Y4L5
P01112
PDB IDs
121P
1AA9
1AGP
1BKD
1CLU
1CRP
1CRQ
1CRR
1CTQ
1GNP
1GNQ
1GNR
1HE8
1IAQ
1IOZ
1JAH
1JAI
1K8R
1LF0
1LF5
1LFD
1NVU
1NVV
1NVW
1NVX
1P2S
1P2T
1P2U
1P2V
1PLJ
1PLK
1PLL
1Q21
1QRA
1RVD
1WQ1
1XCM
1XD2
1XJ0
1ZVQ
1ZW6
221P
2C5L
2CE2
2CL0
2CL6
2CL7
2CLC
2CLD
2EVW
2GDP
2LCF
2LWI
2Q21
2QUZ
2RGA
2RGB
2RGC
2RGD
2RGE
2RGG
2UZI
2VH5
2X1V
3DDC
3I3S
3K8Y
3K9L
3K9N
3KKM
3KKN
3KUD
3L8Y
3L8Z
3LBH
3LBI
3LBN
3LO5
3OIU
3OIV
3OIW
3RRY
3RRZ
3RS0
3RS2
3RS3
3RS4
3RS5
3RS7
3RSL
3RSO
3TGP
421P
4DLR
4DLS
4DLT
4DLU
4DLV
4DLW
4DLX
4DLY
4DLZ
4DST
4DSU
4EFL
4EFM
4EFN
4G0N
4G3X
4K81
4Q21
521P
5P21
621P
6Q21
721P
821P
Enriched GO Terms of Interacting Partners
?
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Proteolysis Involved In Cellular Protein Catabolic Process
Response To Abiotic Stimulus
Cellular Response To Oxygen Levels
Regulation Of Protein Catabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Immune Response-regulating Signaling Pathway
Defense Response
Catabolic Process
Cellular Protein Modification Process
Response To Light Stimulus
Innate Immune Response
Positive Regulation Of Transferase Activity
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Immune Response
Protein Metabolic Process
Mitotic Cell Cycle Process
Toll-like Receptor Signaling Pathway
Protein K63-linked Ubiquitination
Response To Radiation
Cell Cycle Process
Regulation Of Cell Cycle Process
Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Protein Monoubiquitination
Regulation Of Metabolic Process
Response To Hypoxia
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To UV-A
Activation Of Innate Immune Response
Response To Stress
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Catalytic Activity
Neurotrophin Signaling Pathway
Signal Transduction
Positive Regulation Of Catalytic Activity
Neurotrophin TRK Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Signaling
Cell Communication
Small GTPase Mediated Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Positive Regulation Of Metabolic Process
Cellular Response To Stimulus
Ras Protein Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Response To Stimulus
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Ras Protein Signal Transduction
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Cellular Response To Organic Substance
Regulation Of GTPase Activity
Regulation Of Cellular Process
Positive Regulation Of GTPase Activity
Response To Organic Substance
Positive Regulation Of Ras GTPase Activity
Regulation Of Ras GTPase Activity
Regulation Of Phosphorylation
Platelet Activation
Response To Wounding
Positive Regulation Of Protein Modification Process
Epidermal Growth Factor Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Phosphorylation
Regulation Of Immune System Process
Cell Activation
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud
?
12th
arising
arose
carcinogenic
carrying
clustered
codon
contain
detectable
epithelium
find
fraction
gaa
gga
gland
indirectly
mammary
measure
methylurea
mutants
nitroso
nmu
organ
origin
preexisting
sectors
transition
untreated
Tagcloud (Difference)
?
12th
arising
arose
carcinogenic
carrying
clustered
codon
contain
detectable
epithelium
find
fraction
gaa
gga
gland
indirectly
mammary
measure
methylurea
mutants
nitroso
nmu
organ
origin
preexisting
sectors
transition
untreated
Tagcloud (Intersection)
?