RNF115 and IGHA1

Number of citations of the paper that reports this interaction (PMID 22315970)
6

Data Source:
BioGRID (two hybrid)

		RNF115	IGHA1
Gene Name		ring finger protein 115	immunoglobulin heavy constant alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Monomeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Blood Microparticle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Antigen Binding Immunoglobulin Receptor Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Retina Homeostasis Glomerular Filtration Receptor-mediated Endocytosis Immune Response Protein-chromophore Linkage Antibacterial Humoral Response Positive Regulation Of Respiratory Burst
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 RAB7A RAD23A RPL18A SSSCA1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W	1 interactors: RNF115
Entrez ID		27246	3493
HPRD ID		18328
Ensembl ID
Uniprot IDs		Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Oxygen Levels Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-regulating Signaling Pathway Defense Response Catabolic Process Cellular Protein Modification Process Response To Light Stimulus Innate Immune Response Positive Regulation Of Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Immune Response Protein Metabolic Process Mitotic Cell Cycle Process Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination Response To Radiation Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Regulation Of Metabolic Process Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Activation Of Innate Immune Response Response To Stress	Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Autoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Protein Polyubiquitination
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