RNF115 and RPL18A

Number of citations of the paper that reports this interaction (PMID 18819927)
15

Data Source:
BioGRID (two hybrid)

		RNF115	RPL18A
Gene Name		ring finger protein 115	ribosomal protein L18a
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol Membrane Cytosolic Large Ribosomal Subunit
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 RAB7A RAD23A RPL18A SSSCA1 TTR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2I UBE2N UBE2W	10 interactors: AES JUN LPL MAP3K12 MDK NEDD4 RIBC2 RNF115 RPL36 TNK2
Entrez ID		27246	6142
HPRD ID		18328	16045
Ensembl ID			ENSG00000105640
Uniprot IDs		Q9Y4L5	B4DM94 Q02543
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Oxygen Levels Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Immune Response-regulating Signaling Pathway Defense Response Catabolic Process Cellular Protein Modification Process Response To Light Stimulus Innate Immune Response Positive Regulation Of Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Immune Response Protein Metabolic Process Mitotic Cell Cycle Process Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination Response To Radiation Cell Cycle Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Regulation Of Metabolic Process Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV-A Activation Of Innate Immune Response Response To Stress	Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Outflow Tract Morphogenesis Establishment Of Protein Localization To Organelle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Defecation Cellular Response To Potassium Ion Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Targeting Response To Radiation Response To Stress Signal Transduction Negative Regulation Of Binding Response To Drug Protein Localization To Organelle Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Calcium Ion Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Cell Communication Chylomicron Remodeling Positive Regulation Of Anoikis Regulation Of Signal Transduction Protein Polyubiquitination Cytoplasmic Transport Negative Regulation Of Neuron Apoptotic Process Response To Cytokine Progesterone Receptor Signaling Pathway Positive Regulation Of Monocyte Differentiation Positive Regulation Of Sequestering Of Triglyceride Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Cellular Response To Extracellular Stimulus Regulation Of Signaling Catabolic Process Heart Morphogenesis Cell Surface Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway SMAD Protein Import Into Nucleus Very-low-density Lipoprotein Particle Remodeling MAPK Cascade Cellular Macromolecule Catabolic Process
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